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Structural Aberrations of Cellular Sialic Acids and Their Functions in Cancer Metastases

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Journal of shanghai university(English Edition) 2001年第2期5卷 164-170页

作者： LU Da yong, CAO Jing yi school of life {2., shanghai university, shanghai 2.0436 school of life {2. Shanghai University Shanghai

Sialic acids (neuraminic acids) are a special series of 9 carbon ring negatively charged carbohydrates, which has been found to be selectively changed in malignant cells from structures (both synthesis and structure modifications) to functions (up and down regulation in cells). Sialic acids, in single forms or conjugates, have been systematically studied both in lab and in clinics by GC, GC MS, NMR, HPTLC, HPLC and other modern analytical means. Sialic acids and related conjugates are predicted to be used in cancer diagnosis, cancer prognostic forecasting, designing of cancer chemotherapy regimens, uncovering carcinogenetic processes and neoplasm metastasis. Tumor cell regulative systems and pathways are correlated with sialic acids, which can be applied to prognostic evaluation of cancer patients, and antimetastatic chemotherapy by sialic acid derivatives and analogues. Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days. In this paper, main stream discoveries and advancements are provided , also discussions of possible mechanisms and hypotheses are invoked.

关键词： sialic acid neoplasm metastasis cancer diagnosis cancer pathology cancer chemotherapy

Distribution of nimodipine in brain following intranasal administration in rats

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Acta Pharmacologica Sinica 2004年第4期25卷 124-129页

作者： Qi-zhi ZHANG, Xin-guo JIANG2. Chun-hua WU Department of Pharmaceutics, school ofPharmacy, fudan university, {2. 2.0032. China Department of Pharmaceutics School of Pharmacy Fudan University

AIM: To determine whether nasally applied nimodipine (NM) could improve its systemic bioavailability and be transported directly from the nasal cavity to the brain. METHODS: NM was administered nasally, intravenously (iv), and orally to male Sprague-Dawley rats. At different times post dose, blood, cerebrospinal fluid (CSF), and brain tissue samples were collected, and the concentrations of NM in the samples were analyzed byHPLC. RESULTS: Oral systemic bioavailability of NM in rats was 1.17 %, nasal dosing improved bioavailibility to 6..4 %. Following intranasal administration, NM concentrations in olfactory bulb (OB) within 30 min post dose were found significant higher than in the other brain tissues. However, similar NM levels in different brain regions were observed after iv injection. AUC in CSF and OB from the nasal route was 1.2.0}and 1.39 fold compared with the iv route, respectively. The brain-to-plasma AUC ratios were significantly higher after nasal administration than after iv administration (P<0.01). CONCLUSION: Nasally administered NM could markedly improve the bioavailability and a fraction of the NM dose could be transported into brain via the olfactory pathway in rats.

关键词： intranasal administration nimodipine olfactory bulb olfactory pathways

Paleoceanographic evolution recorded in the northern South China Sea since 4 Ma

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Science China Earth sciences 2005年第12期48卷 2166-2173页

作者： HUANG Baoqi1,2. JIAN Zhimin2.& WANG Pinxian2.1. school of Earth and Space sciences, Peking {2., Beijing 100871, China 2. Laboratory of Marine Geology, Tongji {2., shanghai 2.0092. China 1. school of Earth and Space sciences Peking University 100871 Beijing China 2. Laboratory of Marine Geology Tongji University 200092 Shanghai China

Upper water structure over the last 4 million years in the northern South China Sea (SCS) was reconstructed by sea surface temperature (SST) and primary productivity estimated by changes in the abundance of planktonic foraminifer, planktonic foraminifer transfer function, and the accumulation rate of benthic foraminifera. Results of SST and primary productivity show that SST gradually decreased since 4 Ma, but differential seasonal temperature and primary productivity increased in steps mainly at about 3.1, 2.7, 2.1, 1.6. 0.9 and 0.5 Ma. Comparison with tectonics and orbital variations indicates that phased rising of the Tibet since 3.6.Ma, closing of Panama and Indonesian seaways, and orbital changes were responsible for the changes of upper water structure in the SCS, respectively.

关键词： northern South China Sea, upper water structure, Late Pliocene, planktonic foraminifer, ODP 1146.

I-V and C-V properties of TiO_2.thin film by pulsed-laser reactive deposition

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Chinese Science Bulletin 1998年第16期43卷 1344-1349页

作者： FU Zhengwen 1, ZHOU Mingfei 1, ZHANG Shengkun 2.CHEN Lianyao 2.and QIN Qizong 1 1. Laser Chemistry Institute, fudan university, shanghai 2.0433, China 2. Department of Physics, fudan university, shanghai 2.0433, China Laser Chemistry Institute Fudan University Shanghai China Department of Pnysics Fudan University Shanghai China

TiO-2.thin films have bee deposited on p-Si(111) substrates by pulsed-laser ablation of metallic Ti target in the O-3 ambient. The current-voltage and capacitance-voltage of the Al/TiO-2.Si capacitors are measured. The results show that the dielectric constant of thin film after being annealed at 700℃ is found to be 46. and the border trap density and the interface state density at the TiO-2.p-Si interface are 1.8×10 12.cm -2.and 2.10 12.eV -1·cm -2. respectively. The conduction mechanisms of as-deposited films are also discussed.

关键词： TiO-2 dielectric properties electrical properties pulsed-laser deposition.

Global Exact Boundary Controllability for Cubic Semi-linear Wave Equations and Klein-Gordon Equations

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Chinese Annals of Mathematics,Series B 2010年第1期31卷 35-58页

作者： Yi ZHOU Wei XU Zhen LEI Key Laboratory of Mathematics for Nonlinear sciences School of Mathematical Sciences Fudan University Shanghai 200433 China school of Mathematical sciences Fudan University Shanghai 200433 China

The authors prove the global exact boundary controllability for the cubic semilinear wave equation in three space dimensions,subject to Dirichlet,Neumann,or any other kind of boundary controls which result in the well-posedness of the corresponding initial-boundary value *** exponential decay of energy is first established for the cubic semi-linear wave equation with some boundary condition by the multiplier method,which reduces the global exact boundary controllability problem to a local *** proof is carried out in line with [2.15].Then a constructive method that has been developed in [13] is used to study the local *** when the region is star-complemented,it is obtained that the control function only need to be applied on a relatively open subset of the *** the cubic Klein-Gordon equation,similar results of the global exact boundary controllability are proved by such an idea.

关键词： Global exact boundary controllability Cubic semi-linear wave equations The exponential decay Star-shaped Star-complemented Cubic Klein- Gordon equations

Proteomic dissection of biological pathways/processes through profiling protein-protein interaction networks

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Science China Chemistry 2010年第4期53卷 737-746页

作者： CHEN Xian Institutes for Biomedical sciences, fudan university,{2., China Department of Biochemistry & Biophysics, school of Medicine, university of North Carolina-Chapel Hill, USA 1. Institutes for Biomedical sciences Fudan University Shanghai 200433 China2. Department of Biochemistry & Biophysics School of Medicine University of North Carolina-Chapel Hill Chapel Hill USA

Cellular functions, either under the normal or pathological conditions or under different stresses, are the results of the coordinated action of multiple proteins interacting in macromolecular complexes or assemblies. The precise determination of the specific composition of protein complexes, especially using scalable and high-throughput methods, represents a systematic approach toward revealing particular cellular biological functions. In this regard, the direct profiling protein-protein interactions (PPIs) represent an efficient way to dissect functional pathways for revealing novel protein functions. In this review, we illustrate the technological evolution for the large-scale and precise identification of PPIs toward higher physiologically relevant accuracy. These techniques aim at improving the efficiency of complex pull-down, the signal specificity and accuracy in distinguishing specific PPIs, and the accuracy of identifying physiological relevant PPIs. A newly developed streamline proteomic approach for mapping the binary relationship of PPIs in a protein complex is introduced.

关键词： Chen Proteomic dissection of biological pathways/processes through profiling protein-protein interaction networks

Global Classical Solutions to Partially Dissipative Quasilinear Hyperbolic Systems

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Chinese Annals of Mathematics,Series B 2011年第5期32卷 771-780页

作者： Yi ZHOU 11 Key Laboratory of Mathematics for Nonlinear sciences,Ministry of Education,China shanghai Key Laboratory for Contemporary Applied Mathematics {2. of Mathematical sciences,fudan university,shanghai 2.0433,China. Key Laboratory of Mathematics for Nonlinear sciences Ministry of Education China Shanghai Key Laboratory for Contemporary Applied Mathematics School of Mathematical Sciences Fudan University Shanghai 200433 China

The author considers the Cauchy problem for quasilinear inhomogeneous hyperbolic *** the assumption that the system is weakly dissipative,Hanouzet and Natalini established the global existence of smooth solutions for small initial data (in *** ***.,Vol.16.,2.03,pp.89-117).The aim of this paper is to give a completely different proof of this result with slightly different assumptions.

关键词： Cauchy problem Global classical solution Partially dissipativequasilinear hyperbolic system

Jensen's Inequality for Backward Stochastic Differential Equations

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Chinese Annals of Mathematics,Series B 2006年第5期27卷 553-564页

作者： Long JIANG Department of Mathematics, China university of Mining and Technology, Xuzhou 2.1008, Jiangsu, China school of Mathematical {2., fudan university, shanghai 2.0433, China school of Mathematics and System {2., Shandong university, Jinan 2.0100, China. Department of Mathematics China University of Mining Technology Xuzhou 221008 Jiangsu China school of Mathematical sciences Fudan University Shanghai 200433 China school of Mathematics System sciences Shandong University Jinan 250100 China

Under the Lipschitz assumption and square integrable assumption on g, the author proves that Jensen＇s inequality holds for backward stochastic differential equations with generator g if and only if g is independent of y, g（t, 0）≡ 0 and g is super homogeneous with respect to z. This result generalizes the known results on Jensen＇s inequality for gexpectation in [4, 7-9].

关键词： Backward stochastic differential equation g-Expectation Jensen's inequality for g-expectation Jensen's inequality for BSDEs

The adsorption isotherms, IR and ^(2.)Si MAS NMR spectra of modified MCM-41 molecular sieves

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Chinese Science Bulletin 1997年第10期42卷 828-832页

作者： LONG Yingcai, DONG Weiyang, XU Taiming, GAO Xiaoqin, XIE Guangen and SUN Yaojun1. Department of Chemistry, fudan university, shanghai 2.0433, China 2. Centre of Analysis and Measurement, fudan university, shanghai 2.0433, China Department of Chemistry Fudan University Shanghai China Centre of Analysis and Measurement Fudan University Shanghai China

RECENTLY a new family of mesoporous molecular sieves,M41S,was reported by researchers atMobil R&D *** a member of the family,MCM-41,which exhibits a hexagonalarray of uniform channel mesopores,has been *** channel size can be variedfrom approximately 1.5 nm to greater than 10 nm by choosing different surfactants,auxiliarychemicals(1,3,5-trimethylbenzene)in the reactant,and by changing the reaction *** wall thickness of this kind of molecular sieve is in the range of 0.3 to 1.3 nm esti-

关键词： MCM-41 surface modification adsorption isotherm IR 2.Si MAS NMR.