Structural Aberrations of Cellular Sialic Acids and Their Functions in Cancer Metastases

作     者：LU Da yong, CAO Jing yi School of Life Sciences, Shanghai University, Shanghai 200436 LU Da yong, CAO Jing yi School of Life Sciences, Shanghai University, Shanghai 200436

作者机构：School of Life Sciences Shanghai University Shanghai 

出 版 物：《Journal of Shanghai University(English Edition)》 (上海大学学报（英文版）)

年 卷 期：2001年第5卷第2期

页      面：164-170页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：theScienceFoundationofShanghaiMunicipalofEducation!(97A49) 

主　　题：sialic acid neoplasm metastasis cancer diagnosis cancer pathology cancer chemotherapy 

摘      要：Sialic acids (neuraminic acids) are a special series of 9 carbon ring negatively charged carbohydrates, which has been found to be selectively changed in malignant cells from structures (both synthesis and structure modifications) to functions (up and down regulation in cells). Sialic acids, in single forms or conjugates, have been systematically studied both in lab and in clinics by GC, GC MS, NMR, HPTLC, HPLC and other modern analytical means. Sialic acids and related conjugates are predicted to be used in cancer diagnosis, cancer prognostic forecasting, designing of cancer chemotherapy regimens, uncovering carcinogenetic processes and neoplasm metastasis. Tumor cell regulative systems and pathways are correlated with sialic acids, which can be applied to prognostic evaluation of cancer patients, and antimetastatic chemotherapy by sialic acid derivatives and analogues. Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days. In this paper, main stream discoveries and advancements are provided , also discussions of possible mechanisms and hypotheses are invoked.