Polymerase-tautomeric Model for Untargeted Delayed Base Substitution Mutations Formation during Error-prone and SOS Replication of Double-stranded DNA Containing Thymine and Adenine in Some Rare Tautomeric Forms

作     者：Helen A.Grebneva 

作者机构：Donetsk Physical and Technical InstituteNational Academy of Science of Ukraine03680 KievNauky av.46Ukraine 

出 版 物：《Journal of Oncology Research》 (肿瘤学研究杂志（英文）)

年 卷 期：2019年第1卷第2期

页      面：24-37页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Radiation-induced genomic instability Untargeted delayed base substitution mutations UV-mutagenesis Rare tautomeric forms of DNA bases Thymine,adenine Error-prone replication SOS replication 

摘      要：Polymerase-tautomeric model for untargeted delayed base substitution mutations is *** analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymine T3*,adenines A2*and A4*so that between them hydrogen bonds are *** adenine and cytosine can be incorporated opposite canonical thymine *** thymine and guanine can be incorporated opposite canonical adenine *** in the synthesis of DNA containing rare tautomeric forms of thymine T3*,adenines A2*and A4*,involved DNA polymerases with relatively high fidelity of synthesis,mutations not ***,if further DNA synthesis will involve DNA polymerases having a low fidelity of synthesis,there may be base substitution *** was shown that the conclusion made in the Tomasetti and Vogelstein cancer risk model that the formation of about 67%of all mutations was not caused by exposure to any mutagens is erroneous.