Gut microbiota:closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus

作     者：Lu Ding Xin-Hua Xiao Ding Lu;Xiao Xin-Hua

作者机构：Department of EndocrinologyKey Laboratory of EndocrinologyMinistry of HealthPeking Union Medical College HospitalDiabetes Research Center of Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第7期

页      面：817-825页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81870579,81870545,81170736,and 81570715) Beijing Natural Science Foundation(Nos.7202163 and 7172169). 

主　　题：Gut microbiota Circadian clock Type 2 diabetes mellitus Metabolites 

摘      要：Type 2 diabetes mellitus(T2DM),a worldwide epidemic disease,has caused tremendous economic and social burden,but the pathogenesis remains uncertain.Nowadays,the impact of unrhythmic circadian clock caused by irregular sleep and unhealthy diet on T2DM has be increasingly studied.However,the contribution of the endogenous circadian clock system to the development of T2DM has not yet been satisfactorily explored.It is now becoming clear that the gut microbiota and the circadian clock interact with each other to regulate the host metabolism.Considering all these above,we reviewed the literature related to the gut microbiota,circadian clock,and T2DM to elucidate the idea that the gut microbiota is closely tied to the regulation of the circadian clock in the development of T2DM,which provides potential for gut microbiota-directed therapies to ameliorate the effects of circadian disruptions linked to the occurrence and development of T2DM.