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gut Microbiome Alterations in COVID-19

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Genomics, Proteomics & Bioinformatics 2021年第5期19卷 679-688页

作者： Tao Zuo Xiaojian Wu Weiping Wen Ping Lan Guangdong Institute of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China Center for Fecal Microbiota Transplantation Research The Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China Department of Otorhinolaryngology Head and Neck SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510080China Guangzhou Key Laboratory of Otorhinolaryngology Guangzhou 510080China Department of Otorhinolaryngology Head and Neck SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China

Since the outset of the coronavirus disease 2019(COVID-19)pandemic,the gut microbiome in COVID-19 has garnered substantial interest,given its significant roles in human health and *** evidence is unveiling that the gut microbiome is broadly altered in COVID-19,including the bacterial microbiome,mycobiome,and ***,the gut microbial ecological network is significantly weakened and becomes sparse in patients with COVID-19,together with a decrease in gut microbiome *** the existence of severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2),the gut microbiome of patients with COVID-19 is also characterized by enrichment of opportunistic bacteria,fungi,and eukaryotic viruses,which are also associated with disease severity and ***,a multitude of symbiotic bacteria and bacteriophages are decreased in abundance in patients with *** gut microbiome features persist in a significant subset of patients with COVID-19 even after disease resolution,coinciding with‘long COVID’(also known as postacute sequelae of COVID-19).The broadly-altered gut microbiome is largely a consequence of SARS-CoV-2 infection and its downstream detrimental effects on the systemic host immunity and the gut *** impaired host immunity and distorted gut microbial ecology,particularly loss of low-abundance beneficial bacteria and blooms of opportunistic fungi including Candida,may hinder the reassembly of the gut microbiome post *** investigation is necessary to fully understand the role of the gut microbiome in host immunity against SARS-CoV-2 infection,as well as the long-term effect of COVID-19 on the gut microbiome in relation to the host health after the pandemic.

关键词： COVID-19 gut Microbiome Immunity Infection

High-throughput sequencing of 16S r RNA amplicons characterizes gut microbiota shift of juvenile sea cucumber Apostichopus japonicus feeding with three antibiotics

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Journal of Oceanology and Limnology 2019年第5期37卷 1714-1725页

作者： ZHAO Ye WANG Qing LIU Hui LI Bingjun ZHANG Hongxia Ocean School Yantai UniversityYantai 264005China Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China

Sea cucumber Apostichopus japonicus is an important marine economic species in Asian countries due to its profound nutritional and medicinal value. So far, with the rapid development of intensifi ed artifi cial aquaculture of sea cucumbers, the use of antibiotics is still an inexpensive and dispensable way to treat pathogenic infections, especially during the nursery phase. However, there is little information on the eff ects of antibiotics on the intestinal microbiota of sea cucumber. Therefore an Illumina based sequencing method was used to examine the intestinal bacterial composition of juvenile A . japonicas following diets with three typical antibiotics (tetracycline, erythromycin, and norfl oxacin) under 15, 30, and 45 d. The fi ndings reveal that diff erent antibiotics have distinct eff ects on the growth performance of juvenile sea cucumbers. However, the richness and diversity of microbiota were barely aff ected by antibiotics but the community composition alterations indicated that the three antibiotics exhibited their respective patterns of reshaping the intestinal bacteria of juvenile sea cucumbers. In common, the abundance of some sensitive genera with helpful functions, such as Thalassotalea , Shewanella , Sulfi tobacter , and Halomonas decreased signifi cantly with exposure to antibiotics and the abundance of multiple potential pathogenic- and suspected antibiotic-resistant microorganisms like Arcobacter , Leucothrix , and Clostridium_sensu_stricto_1 was found increased signifi cantly in the antibiotic groups. These results suggest that low doses of antibiotics could aff ect the composition of the intestinal microbiota of sea cucumbers and might increase the risk of infection of the hosts. This study could help us to explore how antibacterial compounds modify the gut microbiota of sea cucumbers and provide theoretical guidance in hatchery management by scientifi c antibiotic use in sea cucumber mariculture.

关键词： gut microbiota sea cucumber antibiotic 16S rRNA gene illumina sequencing

Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia

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Acta Pharmaceutica Sinica B 2020年第2期10卷 249-261页

作者： Libin Pan Pei Han Shurong Ma Ran Peng Can Wang Weijia Kong Lin Cong Jie Fu Zhengwei Zhang Hang Yu Yan Wang Jiandong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Insitute of Medicinal Biotechnology Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China

The progression of hyperuricemia disease is often accompanied by damage to renal ***,there are few studies on hyperuricemia nephropathy,especially its association with intestinal *** study combines metabolomics and gut microbiota diversity analysis to explore metabolic changes using a rat model as well as the changes in intestinal flora *** results showed that amino acid metabolism was disturbed with serine,glutamate and glutamine being downregulated whilst glycine,hydroxyproline and alanine being *** combined glycine,serine and glutamate could predict hyperuricemia nephropathy with an area under the curve of *** intestinal flora was also ***,Myroides,Corynebacterium,Alcaligenaceae,Oligella and other conditional pathogens increased significantly in the model group,while Blautia and Roseburia,the shortchain fatty acid producing bacteria,declined *** phylum,family and genus levels,disordered nitrogen circulation in gut microbiota was *** the model group,the uric acid decomposition pathway was enhanced with reinforced urea liver-intestine *** results implied that the intestinal flora play a vital role in the pathogenesis of hyperuricemia ***,modulation of gut microbiota or targeting at metabolic enzymes,i.e.,urease,could assist the treatment and prevention of this disease.

关键词： Hyperuricemia Renal function gut microbiota Metabolomics Urease

gut microbiota variation across generations regarding the diet and life stage in Harmonia axyridis (Coleoptera: Coccinellidae)

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Insect Science 2024年第5期31卷 1365-1377页

作者： Yansong Wang Ping Gao Wenquan Qin Hongran Li Jie Zheng Ling Meng Baoping Li College of Plant Protection Nanjing Agricultural UniversityNanjingChina

We attempt to determine the effect of the dietary switch from a native to non-native prey on the gut microbiota in the predaceous ladybird Harmonia axyridis larvae and adults and examine how the dietary effect may vary across *** fed *** with different diets,native aphid Megoura japonica(Matsumura)versus non-native mealy-bug Phenacoccus solenopsis(Tinsley),for 5 generations and sequenced microbes in the gut of the 3rd instar larvae and adults of the Ist,3rd,and 5th *** addition,we identified microbes in *** and P *** 2 prey species differed in microbial community as measured by abundances of prevalent microbial genera and *** ***,abundances of some prevalent microbial genera differed between the 2 diets in the 1st and 3rd generations,but the difference disappeared in the 5th generation;this tendency is more obvious in adults than in ***,gut microbial assemblages became gradually cohesive over *** diversity differed between diets in the 1st and 3rd generations but became similar in the 5th *** prevalent gut microbial genera are predicted to be associated with metabolic functions of *** and associated genera are more abundant for consuming the mealybug than the *** findings from this study suggest that the gut microbiota in *** is flexible in re-sponse to the dietary switch,but tends toward homogeneity in microbial composition over generations.

关键词： gut harlequin ladybird microbial community microbiome predaceous insects

Characterization and identification of enzyme-producing microflora isolated from the gut of sea cucumberApostichopus japonicus

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Chinese Journal of Oceanology and Limnology 2016年第1期34卷 153-162页

作者：李凤辉高菲谭杰范超晶孙慧玲燕敬平陈四清王肖君 Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071 China College of Fisheries and Life Science Shanghai Ocean University Shanghai 201306 China Zhaoyuan Marine Environmental Monitoring Station Yantai 265400 China

gut microorganisms play an important role in the digestion of their host animals. The purpose of this research was to isolate and assess the enzyme-producing microbes from the Apostichopusjaponicus gut. Thirty-nine strains that can produce at least one of the three digestive enzymes （protease, amylase, and cellulase） were qualitatively screened based on their extracellular enzyme-producing abilities. The enzyme-producing strains clustered into eight groups at the genetic similarity level of 100% by analyzing the restriction patterns of 16S rDNA amplified with Mbo L Phylogenetic analysis revealed that 37 strains belonged to the genus Bacillus and two were members of the genus Virgibacillus. Enzyme-producing capability results indicate that the main enzyme-producing microflora in the *** gut was Bacillus, which can produce protease, amylase, and cellulase. Virgibacillus, however, can only produce protease. The high enzyme-producing capability of the isolates suggests that the gut microbiota play an important role in the sea cucumber digestive process.

关键词： Apostichopusjaponicus gut enzyme-producing microorganisms 16S rDNA-RFLP aquaculture probiotics

Correlation of gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment

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Genomics, Proteomics & Bioinformatics 2019年第1期17卷 26-38页

作者： Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao Shandong Children's Microbiome Center Qilu Children's Hospital of Shandong University Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong University Institute of Child Health Care Qilu Children's Hospital of Shandong University School of Information Science and Engineering Shandong Normal University Research Institute of Pediatrics Qilu Children's Hospital of Shandong University Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang University College of Life Science Qilu Normal University School of Chemistry Beihang University CAS Key Laboratory of Synthetic Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation.

关键词： Autism spectrum disorders gut microbiome Biomarker Mother-child pair Microbiota-gut-immunebrain axis

gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 19-27页

作者： Jian-Wen Jiang Xin-Hua Chen Zhigang Ren Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health First Affiliated Hospital Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University Health Management Center First Affiliated Hospital Zhejiang University School of Medicine Department of Infectious Disease Precision Medicine Center the First Affiliated Hospital of Zhengzhou University

Background: Hepatocellular carcinoma(HCC) is one of the most common malignancies in the world. gut microbiota has been demonstrated to play a critical role in liver inflammation, chronic fibrosis, liver cirrhosis, and HCC development through the gut-liver axis. Data sources: Recently there have been several innovative studies investigating gut microbial dysbiosismediated enhancement of HCC through the gut-liver axis. Literatures from January 1998 to January 2018 were searched in the Pub Med database using the keywords "gut microbiota" and "hepatocellular carcinoma" or "liver cancer", and the results of experimental and clinical studies were analyzed. Results: gut microbial dysbiosis accompanies the progression of alcoholic liver disease, non-alcoholic fatty liver disease and liver cirrhosis, and promotes HCC progression in an experimental mouse model. The immune system and key factors such as Toll-like receptor 4 are involved in the process. There is evidence for gut microbial dysbiosis in hepatitis virus-related HCC patients. Conclusions: gut microbial dysbiosis is closely associated with hepatic inflammation disease and HCC through the gut-liver axis. With the enhanced understanding of the interactions between gut microbiota and liver through the gut-liver axis, new treatment strategies for HCC are being developed.

关键词： gut-liver axis gut microbiota Hepatocellular carcinoma Lipopolysaccharide Toll-like receptor 4

gut microbiota have blood types as human

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Science Bulletin 2018年第20期63卷 1311-1313页

作者： Qizheng Wu Hui Zhong Yafei Zhai Yanjiong Jia Zhinan Yin Min Chen Hengwen Yang Peng George Wang The State Key Laboratory of Microbial Technology and National Glycoengineering Research Center Shandong University The First Affiliated Hospital Biomedical Translational Research Institute Guangdong Province Key Laboratory of Molecular Immunology and Antibody EngineeringJinan University

ABO blood group system was firstly recognized by Landsteiner in 1900[1].Since then,the antigens of the ABO system (A,B and H determinants,respectively)have been shown to encompass complex carbohydrate structures [2].A and B antigen were synthesized by the sequential action of glycosyltransferases,with A and B glycosyltransferases catalyzing the addition of N-acetylgalactosamine and D-galactose to precursor H antigen,respectively. Group O individuals lack such transferase enzymes and consequently continue to express the basic H structure only [3,4].It is determined that approximate 2million ABH glycan antigen sites are presented on each red blood cell [5].Additionally,the ABH antigens are widely expressed in other human ceils and tissues,including the sensory neurons,epithelium,the vascular endothelium and platelets [6].

关键词： gut microbiota blood types

Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens

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Journal of Animal Science and Biotechnology 2019年第1期10卷 218-230页

作者： Shengru Wu Yanli Liu Yongle Duan Fangyuan Wang Fangshen Guo Fang Yan Xiaojun Yang Xin Yang College of Animal Science and Technology Northwest A&F University College of animal science and Technology Hebei Agricultural University

Background: Limited research has focused on the effect of Lactobacillus on the intestinal toxicity of deoxynivalenol(DON).The present study was conducted to investigate the role of Lactobacillus plantarum(***) JM113 in protecting against the intestinal toxicity caused by ***: A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments,including the CON(basal diet),the DON(extra 10 mg/kg deoxynivalenol),and the DL(extra 1 × 109 CFU/kg *** JM113 based on DON group) *** growth performance,organ indexes,intestinal morphology,pancreatic digestive enzymes,intestinal secreted immunoglobulin A(sIgA),jejunal transcriptome,and intestinal microbiota were ***: Compared with the CON and DL groups,the DON supplementation altered intestinal morphology,especially in duodenum and jejunum,where villi were shorter and crypts were deeper(P < 0.05).Meanwhile,the significantly decreased mRNA expression of jejunal claudin-1 and occludin(P < 0.05),ileal rBAT and jejunal GLUT1 of 21-day-old broilers(P < 0.05),as well as duodenal PepT1 and ileal rBAT of 42-day-old broilers were identified in the DON ***,supplementation with *** JM113 could increase duodenal expression of IL-10 and IL-12 of 21-dayold broilers,ileal s IgA of 42-day-old broilers,and the bursa of Fabricius index of 21-day-old *** jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra *** ***,the bacteria related to nutrient utilization,including the Proteobacteria,Escherichia,Cc-115(P < 0.05),Lactobacillus and Prevotella(P < 0.1) were all decreased in the DON *** contrast,supplementation with *** JM113 increased the relative abundance of beneficial bacterium,including the Bacteroidetes,Roseburia,Anaerofustis,Anaerostipe,and Ruminococcus

关键词： Broiler chickens Deoxynivalenol gut microbiota Lactobacillus plantarum JM113 mRNA sequencing 16S rRNA gene sequencing