Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

作     者：Caroline Dani Isabel Teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da Silva Simone Nique Vera Striebel Daniela Pochmann Viviane Rostirola Elsner 

作者机构：Programa de Pos Graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IPAPorto AlegreRSBrazil Curso de Fisioterapia do Centro Universitario Metodista-IPAPorto AlegreRSBrazil Programa de Pos Graduacao em Ciencias Biologicas:FisiologiaUniversidade Federal do Rio Grande do SulPorto AlegreRSBrazil Programa de Pos Graduacao em Farmacologia e TerapeuticaUniversidade Federal do Rio Grande do SulPorto AlegreRSBrazil 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第11期

页      面：2067-2072页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：financially supported by Coordenacao de Aperfei a oamento de Pessoal de Nível Superior(CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Fundacao de AmparoàPesquisa do Estado do Rio Grande do Sul(FAPERGS)for financial support。 

主　　题：antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress Parkinson's disease 

摘      要：Parkinson s disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this disease.Physical exercise can regulate oxidative stress.The purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson s disease.The aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise program.Our results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson s disease.Compared with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session.Our results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme activity.These results could better help understand the target of oxidative stress in Parkinson s disease.This study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).