Exercise promotes recovery after motoneuron injury via hormonal mechanisms
Exercise promotes recovery after motoneuron injury via hormonal mechanisms作者机构:Psychological and Brain Sciences Indiana University
出 版 物:《Neural Regeneration Research》 (中国神经再生研究(英文版))
年 卷 期:2020年第15卷第8期
页 面:1373-1376页
核心收录:
学科分类:0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程(可授工学、理学学位)]
基 金:supported by NIH-NINDS NS047264 to DRS
主 题:axon regeneration axotomy dendritic morphology exercise hormones neuroprotection neurotrophins
摘 要:Injuries to spinal motoneurons manifest in a variety of forms,including damage to peripheral axons,neurodegenerative disease,or direct insult *** injuries produce a variety of negative structural and functional changes in both the directly affected and neighboring *** is a relatively simple behavioral intervention that has been demonstrated to protect against,and accelerate recovery from,these negative *** this article,we describe how exercise is neuroprotective for motoneurons,accelerating axon regeneration following axotomy and attenuating dendritic atrophy following the death of neighboring *** both of these injury models,the positive effects of exercise have been found to be dependent on gonadal hormone *** we describe a model in which exercise,hormones,and brain-derived neurotrophic factor might all interact to produce neuroprotective effects on motoneuron structure following neural injury.