Effect of graphene oxide exposure on intestinal Wnt signaling in nematode Caenorhabditis elegans

作     者：Peidang Liu Huimin Shao Yan Kong Dayong Wang Peidang Liu;Huimin Shao;Yan Kong;Dayong Wang

作者机构：Key Laboratory of Environmental Medicine Engineering in Ministry of EducationMedical SchoolSoutheast UniversityNanjing 210009China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2020年第32卷第2期

页      面：200-208页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81771980 81571805) 

主　　题：Graphene oxide Intestinal Wnt signaling Caenorhabditis elegans 

摘      要：Exposure to engineered nanomaterials(ENMs), such as graphene oxide(GO), can potentially induce the response of various molecular signaling pathways, which can mediate the protective function or the toxicity *** signaling pathway is conserved evolutionarily in *** Caenorhabditis elegans as an in vivo assay model, we investigated the effect of GO exposure on intestinal Wnt *** the intestine, GO exposure dysregulated Frizzled receptor MOM-5, Disheveled protein DSH-2, GSK-3(a component of APC complex), and two β-catenin proteins(BAR-1 and HMP-2), which mediated the induction of GO *** GO exposed nematodes, a Hox protein EGL-5 acted as a downstream target of BAR-1, and fatty acid transport ACS-22 acted as a downstream target of *** analysis on HMP-2 and ACS-22 suggested that the dysregulation of these two proteins provides an important basis for the observed deficit in functional state of intestinal *** results imply the association of dysregulation in physiological and functional states of intestinal barrier with toxicity induction of GO in organisms.