Oxidative stress and antioxidants in hepatic pathogenesis

作     者：Hye-Lin Ha Hye-Jun Shin Mark A Feitelson Dae-Yeul Yu 

作者机构：Disease Model Research LaboratoryAging Research CenterKorea Research Institute of Bioscience and Biotechnology Department of Functional GenomicsUniversity of Science and Technology Department of BiologyCollege of Science and TechnologyTemple University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第48期

页      面：6035-6043页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by The 21st Century Frontier Program in the Functional Human Genome Project, No. HGM0200934 the International Collaboration Program of Science and Technology, No. FGM0600914 the Ministry of Education, Science and Technology, and the KRIBB Research Initiative Program Grant, No. KGM3320911, South Korea 

主　　题：Hepatitis B virus Hepatitis B virus X protein Alcohol Chronic liver disease Oxidative stress Antioxidant 

摘      要：Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases,including hepatocellular carcinoma (HCC). The HBV encod-ed proteins,hepatitis B virus X protein and preS,appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress,which can damage cellular molecules like lipids,proteins,and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants,such as curcumin,silymarin,green tea,and vitamins C and E,can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis,focusing upon HBV and alcohol,and suggests antioxidant therapeutic approaches.