Therapeutic effects of garlic in cardiovascular atherosclerotic disease

作     者：Igor A.Sobenin Veronika A.Myasoedova Maria I.Iltchuk ZHANG Dong-Wei Alexander N.Orekhov 

作者机构：National Medical Research Center of Cardiology121552 MoscowRussian Federation Institute of General Pathology and Pathophysiology125315 MoscowRussian Federation Research Institute of Threpsology and Healthy Lo ngevityPlekhanov Russian University of Economics117997 MoscowRussian Federation Diabetes Research CenterTraditional Chinese Medicine SchoolBeijing University of Chinese MedicineBeijing 100029China Institute of Human Morphology117418 MoscowRussian Federation 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2019年第17卷第10期

页      面：721-728页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Russian Science Foundation(No.19-15-00010) 

主　　题：Atherosclerosis Dyslipidemia Cardiovascular disease Natural medicines Garlic 

摘      要：Garlic(Allium sativum) is a widely known medicinal plant, potential of which remains to be fully evaluated. Its wide-range beneficial effects appear to be relevant for treatment and prevention of atherosclerosis and related diseases. It is generally believed that garlic-based preparations are able to improve lipid profile in humans, inhibit cholesterol biosynthesis, suppress low density lipoprotein oxidation, modulate blood pressure, suppress platelet aggregation, lower plasma fibrinogen level and increase fibrinolytic activity, thus providing clinically relevant cardioprotective and anti-atherosclerotic effects. It is important to assess the level of evidence available for different protective effects of garlic and to understand the underlying mechanisms. This information will allow adequate integration of garlic-based preparations to clinical practice. In this review, we discuss the mechanisms of anti-atherosclerotic effects of garlic preparations, focusing on antihyperlipidemic, hypotensive, anti-platelet and direct anti-atherosclerotic activities of the medicinal plant. We also provide an overview of available meta-analyses and a number of clinical trials that assess the beneficial effects of garlic.