Application of Newcastle disease virus in the treatment of colorectal cancer
Application of Newcastle disease virus in the treatment of colorectal cancer作者机构：National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Biotargeting Theranostics Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy Guangxi Medical University
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2019年第7卷第16期
页 面：2143-2154页
核心收录：
学科分类：10[医学]
主 题：Newcastle disease virus Exogenous gene Armed virus Oncolytic therapy Colorectal cancer
摘 要：Colorectal cancer (CRC) is one of the main reasons of tumor-related deaths *** present,the main treatment is surgery,but the results are unsatisfactory,and the prognosis is *** majority of patients die due to liver or lung metastasis or *** recent years,great progress has been made in the field of tumor gene therapy,providing a new treatment for combating *** oncolytic viruses selectively replicate almost exclusively in the cytoplasm of tumor cells and do not require integration into the host genome,they are safer,more effective and more attractive as oncolytic *** disease virus (NDV) is a natural RNA oncolytic *** NDV selectively infects tumor cells,the immune response induced by NDV’s envelope protein and intracellular factors can effectively kill the tumor without affecting normal *** genetic techniques make NDV a vector for gene *** the virus by inserting various exogenous genes or using NDV in combination with immunotherapy can also improve the anti-CRC capacity of NDV,and good results have been achieved in animal models and clinical treatment *** article reviews the molecular biological characteristics and oncolytic mechanism of NDV and discusses in vitro and in vivo experiments on NDV anti-CRC capacity and clinical *** conclusion,NDV is an excellent candidate for cancer treatment,but more preclinical studies and clinical trials are needed to ensure its safety and efficacy.
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