Transmission of hepatitis C virus: Self-limiting hepatitis or chronic hepatitis?

作     者：Takafumi Saito Yoshiyuki Ueno 

作者机构：Department of GastroenterologyYamagata University School of MedicineYamagata 990-9585Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第41期

页      面：6957-6961页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Hepatitis C Spontaneous clearance Interleukin 28B Single nucleotide polymorphism Interferon-λ 

摘      要：It has been suggested that hepatitis C virus(HCV)is selectively transmitted to a new host as an infectious clone from multiple HCV variants(quasispecies)in the *** individuals with HCV infection develop chronic hepatitis,but approximately 15%-40%of them clear the virus spontaneously and the hepatitis is resolved in a self-limiting manner in the acute phase of *** difference in the outcome of acute hepatitis C is attributable to both viral characteristics and genetic regulation of *** particular,the evolutionary dynamics of the infecting virus and host genetic polymorphisms pertaining mainly to the immune system,including polymorphisms in the region of the Interleukin 28B gene encoding interferon-λ-3,are associated with susceptibility to HCV infection.