Angiogenesis and neuronal remodeling after ischemic stroke

作     者：Masahiro Hatakeyama Itaru Ninomiya Masato Kanazawa Masahiro Hatakeyama;Itaru Ninomiya;Masato Kanazawa

作者机构：Department of Neurology Brain Research Institute Niigata University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第1期

页      面：16-19页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a Grant-in-Aid for Scientific Research(Research Project No.15K19478 and 18K07493,both to MK) Japan Science and Technology Agency(JST),the Translational Research program Strategic Promotion for practical application of Innovative medical Technology(TR-SPRINT)supported by Japan Agency for Medical Research and Development(AMED)under Grant No.JP19lm0203023 a grant from Takeda Science Foundation the Bayer Scholarship for Cardiovascular Research Japan Cardiovascular Research Foundation Astellas Foundation for Research on Metabolic Disorders Young Investigator Okamoto Award Medical Research Encouragement Prize of the Japan Medical Association(to MK) supported by a grant from Tsubaki Memorial Foundation(to MH and IN) 

主　　题：angiogenesis axonal outgrowth cerebral ischemia coupling functional recovery guidance neurogenesis stroke 

摘      要：Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal *** raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic *** vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a *** this mini-review,we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral *** occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and ***-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional ***,new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin ***,blood vessels are thought to enhance neurogenesis in three stages:1)Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals,2)microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen,nutrients,and soluble factors as well as serving as a scaffold for migration,and 3)oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature ***,the regions of angiogenesis and surrounding tissue may be coupled,representing novel treatment targets.