Correlation of angiotensin converting enzyme gene polymorphism with perioperative myocardial protection under extracorporeal circulation

作     者：Wei Yang Xiao Dong Bin Li Xiao-Qiang Zhang Yuan Zeng Yi-Ping Wei Jian-Liang Zhou Yan-Hua Tang Jian-Jun Xu 

作者机构：Department of Cardiothoracic SurgerySecond Affiliated Hospital to Nanchang University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第12期

页      面：995-999页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Angiotensin converting enzyme ACE gene polymorphism Cardiopulmonary bypass perioperative Myocardial injury Myocardial markers 

摘      要：Objective:To observe the expression of angiotensin converting enzyme(ACE),angiotensinⅡ(AngⅡ),cardiac troponin cTnⅠ),creatine kinase isozymes(CK-MB) and muscle red protein(Myo) after cardiopulmonary bypass(CPB),and to investigate the association of polymorphisms in angiotensin converting enzyme genes and myocardial ***:Sixty-three patients suffered from rheumatic mitral stenosis and scheduled for mitral valve replacement with CPB, were randomly divided into three groups according polymorphisms in angiotensin converting enzyme genes:typeⅡ,type ID,type DD(each=21).Blood samples were withdrawn from artery before operation(T1),at the beginning of CPB(T2),30 min after CPB(T3),(T4) at the end of CPB(T5), 2 h after CPB(T6),6 h after CPB(17) to measure the expression of ACE,AngⅡ,cTnⅠ,CK-MB, ***:The level of ACE during and after CPB were significantly higher than those before CPB(P0.05).As extension of CPB time,the expression of ACE was *** level of cTnⅠ, CK-MB,Myo after CPB were significantly higher than those before CPB(P0.05).The level of cTnⅠ,CK-MB and Myo were highest at T7,T6 and T5 and T7,*** level of ACE,AngⅡ,cTnⅠin patients with DD genotype was significantly higher than the ID andⅡgenotype(P 0.05).Besides,the level of ACE,AngⅡin patients with ID genotype was significantly higher than the II(P 0.05).Conclusions:There is certain correlation between CPB perioperative midterm ACE and cTnⅠ,Myo,*** DD genotype is a susceptibility gene of the CPB perioperative myocardial injury.