Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up

作     者：Andrea Sansone Danilo Alunni Fegatelli Carlotta Pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo Andrea Lenzi Daniele Gianfrilli 

作者机构：Departme nt of Experime ntal Medici ne Sa pie nza Un iversity of Rome Rome 00161 Italy Department of Public Health and In fectious Diseases Sapienza University of Rome Rome 00161 Italy Unit of Endocrinology Regina Elena National Cancer Institute Rome 00144 Italy Vascular and Interventional Radiology Unit Department of Radiological Oncological and Anatomo-Pathological Sciences Sapienza-University of Rome Rome 00161 Italy 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2019年第21卷第4期

页      面：408-412页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：catch-up growth percutaneous treatment testicular hypotrophy testicular ultrasound testicular volume varicocele young adults 

摘      要：Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular catch-up growth in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies.