ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI
ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI作者机构：Department of Neurology Xuanwu Hospital of Capital Medical University Beijing 100053 China Department of Radiology Chinese PLA General Hospital Beijing 100853 China Université Normandie Inserm Université de Caen-Normandie Inserm UMR-S U1237 GIP Cyceron Caen 14000 France Department of Radiology Tianjin Huanhu Hospital Tianjin 300350 China Department of Radiology Tianjin Medical University General Hospital Tianjin 300052 China Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing 100053 China Beijing Institute of Geriatrics Beijing 100053 China National Clinical Research Center for Geriatric Disorders Beijing 100053 China Brainnetome Center & National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing 100049 China Center for Excellence in Brain Science and Intelligence Technology Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Neurology Qilu Hospital of Shandong University Ji'nan 250012 China Department of Neurology Tianjin Huanhu Hospital Tianjin 300350 China Institute of Geriatrics and Gerontology Chinese PLA General Hospital Beijing 100853 China Department of Radiology Qilu Hospital Ji'nan 250012 China Department of Radiology Xuanwu Hospital of Capital Medical University Beijing 100053 China
出 版 物：《Science Bulletin》 (科学通报（英文版）)
年 卷 期：2019年第64卷第14期
页 面：998-1010页
核心收录：
基 金：supported by the National Key Research and Development Program of China (2016YFC1305904, 2016YFC1306300) the National Natural Science Foundation of China (81871438, 61633018, 81571062, 81471120, 61431012, 81430037) the Strategic Priority Research Program (B) of Chinese Academy of Sciences (XDB32020200) the Beijing Municipal Commission of Health and Family Planning (PXM2019_026283_000002)
主 题：Brain spontaneous activity Multisite Biomarkers Leave-one-site-out cross-validation Alzheimer's disease
摘 要：Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer s disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer s meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P??0.05, Bonferroni corrected) between the normalized amplitude index and Mini-Mental State Examination scores were found in the identified brain regions, which indicates that the altered brain activity was associated with cognitive decline in the patients. Multivariate analysis and leave-one-site-out cross-validation led to a 78.49% prediction accuracy for single-patient classification. The altered activity patterns of the identified brain regions were largely correlated with the FDG-PET results from another independent study. These results emphasized the impaired brain activity to provide a robust and reproducible imaging signature of AD.
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