GC-MS analysis and anti-mosquito activities of Juniperus virginiana essential oil against Anopheles stephensi(Diptera: Culicidae)
GC-MS analysis and anti-mosquito activities of Juniperus virginiana essential oil against Anopheles stephensi(Diptera: Culicidae)作者机构：Department of Clinical Research Pasteur Institute of Iran Malaria and Vector Research Group Biotechnology Research Center Pasteur Institute of Iran Department of Parasitology Pasteur Institute of Iran Research Center for Health Sciences Institute of Health Shiraz University of Medical Sciences Department of Medical Entomology and Vector Control School of Public health Tehran University of Medical sciences Research Center for Health Sciences Institute of Health Department of Occupational Health Engineering School of Health Shiraz University of Medical Sciences
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2019年第9卷第4期
页 面：168-175页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：The pilot study of this research was initiated in the National Insectary of Iran located at the Production and Research Complex of the IPI and was fulfilled in the Insectaries of the School of Public Health Shiraz University of Medical Sciences. The authors wish to thank the staffs of both Insectaries especially Ms. Marziae Shahriari-Namadi. This research was financially supported by N Maleki-Ravasan & A Tahghighi
主 题：Malaria Pesticide Essential oils Natural products Resistance
摘 要：Objective: To investigate phytochemicals present in the essential oil from aerial parts of eastern red cedar, Juniperus virginiana(J. virginiana) L.(Cupressaceae) and to determine its killing and repellent activities against larvae, pupae, and adults of the Asian malaria mosquito, Anopheles stephensi(Diptera: Culicidae). Methods: J. virginiana essential oil was extracted by hydrodistillation, and its chemical composition was determined by gas chromatography-mass spectrometry. Seven different logarithmic concentrations of J. virginiana essential oils were used in larvicidal and pupicidal assays. J. virginiana essential oils-impregnated bed nets were applied in a designed animal module to test excito-repellent activity against adult mosquitoes. Results: Fourteen constituents corresponding to 99.98% of J. virginiana essential oils were identified. Five main components were terpinen-4-ol(25.21%), camphor(19.89%), E-3-hexen-1-ol(13.30%), γ-terpinene(7.86%), and l-menthone(2.27%). The LC_(50) and LC_(90) values against larvae of the Anopheles stephensi were 11.693 and 66.140 ppm and for pupae were 9.640 and 40.976 ppm, respectively. In excito-repellency assay, J. virginiana essential oilsimpregnated bed nets provided an average of 54.63% protection for guinea pig and 45.37% mortality for the mosquitoes. Conclusions: Four monoterpenes and one leaf alcohol were identified by gas chromatographymass spectrometry. J. virginiana essential oils showed potent larvicidal, pupicidal, adulticidal, and repellent activities against Anopheles stephensi at acceptable concentrations. Evaluation of bioactivity of identified chemicals(alone or in combination) will provide new eco-friendly substances for mosquito-management programs.
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