A model of NSCLC microenvironment predicts optimal receptor targets

作     者：Chuang Han Yu Wu 

作者机构：Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvineeZhejiang UniversityHangzhou 310027China Soft Matter Research CenterZhejiang UniversityHangzhou 310027China 

出 版 物：《Frontiers of Electrical and Electronic Engineering in China》 (中国电气与电子工程前沿（英文版）)

年 卷 期：2019年第7卷第2期

页      面：147-161页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 09[农学] 0701[理学-数学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：the National Natural Science Foundation of China (Nos.11402227,11621062 and 11432012) the Fundamental Research Funds for the Central Universities of China (No.20I5QNA4034) the Thousand Young Talents Program of China 

主　　题：non-small-cell lung cancer tumor microenvironment intercellular signaling network logistic population dynamics drug resistance multi-target therapy 

摘      要：Background:Tumor microenvironment plays an essential role in the growth of *** how tumor cells co-evolve with tumor-associated immune cells and stromal cells is important for tumor ***:In this paper,we propose a logistic population dynamics model for quantifying the intercellular signaling nebvork in non-small-cell lung cancer (NSCLC).The model describes the evolutionary dynamics of cells and signaling proteins and was used to predict effective receptor targets through combination strategy ***,we optimized a multi-target strategy analysis algorithm that was verified by applying it to virtual patients with heterogeneous ***,to deal with acquired resistance which was commonly observed in patients with NSCLC,we proposed a novel targeting strategy-tracking targeted therapy,to optimize the treatment by improving the therapeutic strategy ***:The synergistic effect when inhibiting multiple signaling pathways may help significantly retard carcinogenic processes associated with disease progression,compared with suppression of a single signaling *** traditional treatment (surgery,radiotherapy and chemotherapy) tends to attack tumor cells directly,the multi-target therapy we suggested here is aimed to inhibit the development of tumor by emasculating the relative competitive advantages of tumor cells and promoting that of normal ***:The combination of traditional and targeted therapy,as an interesting experiment,was significantly more effective in treatment of virtual patients due to a clear complementary relationship between the two therapeutic schemes.