Intraarterial chemotherapy with gemcitabine and cisplatin in locally advanced or recurrent penile squamous cell carcinoma

作     者：Jian-Ye Liu Yong-Hong Li Zhuo-Wei Liu Zhi-Ling Zhang Yun-Lin Ye Kai Yao Hui Han Zi-Ke Qin Fang-Jian Zhou 

作者机构：State Key Laboratory of Oncology in South China Department of UrologySun Yat-sen University Cancer Center 

出 版 物：《Chinese Journal of Cancer》 (Chinese Journal of Cancer)

年 卷 期：2013年第32卷第11期

页      面：619-623页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：We appreciate the cooperation from the doctors (Professor Pei-Hong Wu and Jin-Hua Huang et al.) of the Department of Imaging and Interventional Radiology  and the help from the doctors (Professor Dong-Geng Liu and Xiao-Yu Teng et al.) of the Sixth Department of the Chemotherapy at Sun Yat-sen University Cancer Center 

主　　题：鳞状细胞癌 治疗效果 复发 阴茎 晚期 化疗 动脉 灌注 

摘      要：The prognosis of locally advanced or recurrent squamous cell carcinoma(SCC) of the penis after conventional treatment is dismal. This study aimed to evaluate the therapeutic effects of intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced or recurrent SCC of the penis. Between April 1999 and May 2011, we treated 5 patients with locally advanced penile SCC and 7 patients with recurrent disease with intraarterial chemotherapy. The response rate and toxicity data were analyzed, and survival rates were calculated. After 2 to 6 cycles of intraarterial chemotherapy with gemcitabine and cisplatin, 1 patients with locoregionally advanced disease achieved a complete response, and 4 achieved partial response. Of the 7 patients with recurrent disease, 2 achieved complete response, 3 achieved partial response, 3 had stable disease, and 1 developed progressive disease. An objective tumor response was therefore achieved in 10 of the 12 patients. The median overall survival for the patients was 24 months(range, 10-50 months). Three out of 10 patients who responded were long-term survivors after intraarterial chemotherapy. Intraarterial chemotherapy with gemcitabine and cisplatin may be effective and potentially curative in locoregionally advanced or recurrent penile SCC. The contribution of this therapy in the primary management of advanced or recurrent penile SCC should be prospectively investigated.