Functional interactions between steroid hormones and neurotrophin BDNF

作     者：Tadahiro Numakawa Daisaku Yokomaku Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi 

作者机构：Department of Mental Disorder ResearchNational Institute of NeuroscienceNational Center of Neurology and Psychiatry Core Research for Evolutional Science and Technology ProgramJapan Science and Technology Agency Brain Research Centre and Department of PsychiatryUniversity of British Columbia The Center for Neuropharmacology and NeuroscienceAlbany Medical College 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2010年第1卷第5期

页      面：133-143页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Supported by Research Grants for Nervous and Mental Disorders from the Ministry of Health,Labor and Welfare Health and Labor Sciences Research Grants (Research on Psychiatric and Neurological Diseases and Mental Health) Health and Labor Sciences Research Grants,a grant from the Japan Foundation for Neuroscience and Mental Health the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (Kunugi H) a Grant-in-Aid for Young Scientists (A) (21680034) from the Ministry of Education,Culture,Sports,Science,and Technology of Japan (Numakawa T) 

主　　题：Brain-derived neurotrophic factor Steroid hormones Neurotrophin Glucocorticoid Estrogen Tropomyosin-related kinase Extracellular signal-regulated protein kinase Phospholipase Cγ Phosphoinositide 3-kinase 

摘      要：Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS) .Though BDNF has two types of receptors,high affinity tropomyosin-related kinase(Trk) B and low affinity p75 receptors,BDNF positively exerts its biological effects on neurons via activation of TrkB and of resultant intracellular signaling cascades including mitogenactivated protein kinase/extracellular signal-regulated protein kinase,phospholipase Cγ,and phosphoinositide 3-kinase ***,it is possible that alteration in the expression and/or function of BDNF in the CNS is involved in the pathophysiology of various brain diseases such as stroke,Parkinson s disease,Alzheimer s disease,and mental *** the other hand,glucocorticoids,stress-induced steroid hormones,also putatively contribute to the pathophysiology of ***,in addition to the reduction in BDNF levels due to increased glucocorticoid exposure,current reports demonstrate possible interactions between glucocorticoids and BDNF-mediated neuronal functions. Other steroid hormones,such as estrogen,are involved in not only sexual differentiation in the brain,but also numerous neuronal events including cell survival and synaptic ***,it is well known that estrogen plays a role in the pathophysiology of Parkinson s disease,Alzheimer s disease,and mental illness,while serving to regulate BDNF expression and/or ***,we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones(glucocorticoids and estrogen).