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Fatty liver is associated with an increased risk of diabetes and cardiovascular disease- Evidence from three different disease models: NAFLD, HCV and HIV

Fatty liver is associated with an increased risk of diabetes and cardiovascular disease- Evidence from three different disease models: NAFLD, HCV and HIV

作     者:Amedeo Lonardo Stefano Ballestri Giovanni Guaraldi Fabio Nascimbeni Dante Romagnoli Stefano Zona Giovanni Targher 

作者机构:Division of Internal Medicine and Metabolism Nuovo Ospedale Civile Sant'Agostino Estense - Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia and Azienda Ospedaliera of Modena Internal Medicine Pavullo Hospital Azienda Ospedaliera of Modena Section of Infectious Diseases Department of Medicine University of Modena Section of Endocrinology Diabetes and Metabolism Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2016年第22卷第44期

页      面:9674-9693页

核心收录:

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主  题:Atherosclerosis Cardiovascular risk Fatty liver Fibrosis Hepatitis C-associated dysmetabolic syndrome Hepatitis C virus Human immunodeficiency virus Nonalcoholic fatty liver disease Steatohepatitis Steatosis Virus-associated fatty liver disease 

摘      要:Fatty liver, which frequently coexists with necroinflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease(NAFLD) and chronic infections due to either hepatitis C virus(HCV) or human immunodeficiency virus(HIV). These three pathologic conditions are associated with an increased prevalence and incidence of cardiovascular disease(CVD) and type 2 diabetes(T2D). In this multidisciplinary clinical review, we aim to discuss the ever-expanding wealth of clinical and epidemiological evidence supporting a key role of fatty liver in the development of T2 D and CVD in patients with NAFLD and in those with HCV or HIV infections. For each of these three common diseases, the epidemiological features, pathophysiologic mechanisms and clinical implications of the presence of fatty liver in predicting the risk of incident T2 D and CVD are examined in depth. Collectively, the data discussed in this updated review, which follows an innovative comparative approach, further reinforce the conclusion that the presence of fatty/inflamed/fibrotic liver might be a shared important determinant for the development of T2 D and CVD in patients with NAFLD, HCV or HIV. This review may also open new avenues in the clinical and research arenas and paves the way for the planning of future, well-designed prospective and intervention studies.

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