Chronic kidney disease after radical nephrectomy for suspected renal cancers

作     者：Tuck Y Yong Kareeann SF Khow 

作者机构：Internal MedicineFlinders Private Hospital Adelaide Geriatrics Teaching and Research with Aged Carethe University of Adelaide 

出 版 物：《World Journal of Clinical Urology》 (世界临床泌尿杂志)

年 卷 期：2017年第6卷第1期

页      面：10-17页

学科分类：10[医学] 

主　　题：Nephrectomy Renal function Renal cell carcinoma Chronic kidney disease Prevention 

摘      要：Nephrectomy is the treatment of choice for early stage renal cell carcinoma. However,radical nephrectomy is consistently associated with higher rates of newonset chronic kidney disease(CKD) than the general population,regardless of the method used in measuring renal function. The higher rates of CKD are associated with worsened survival because of increased risk of cardiovascular diseases and mortality. Comorbidities and adjacent non-neoplastic kidney diseases are important risk factors for the development of CKD after nephrectomy. Partial nephrectomy has become the standard of care for patients with stage 1a tumours(diameter 4 cm) and an attractive option for those with stage 1b(diameter 4-7 cm). Therefore stratifying the risk of postoperative CKD before surgery is important and ongoing monitoring of kidney function after radical nephrectomy is needed in addition to oncological surveillance. More research is needed to better understand the risk of CKD after radical nephrectomy and develop effective strategies to optimize kidney function after such surgery.