Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina
Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina作者机构：Department of Veterinary Physiology Biochemistry and Pharmacology College of Veterinary Medicine Michael Okpara University of Agriculture
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2012年第2卷第6期
页 面：430-432页
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
主 题：Rauwolfia serpentina Castor oil Antidiarrhoeal activity Intestinal transit
摘 要：Objective:To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina(R. serpentina) in experimental diarrhoea induced by castor oil in ***:Doses of 100, 200 and 400 mg/kgR. serpentinaleaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal ***:All doses of the extract and the reference drug atropine sulphate(3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl(5 mg/kg, p.o.).Conclusions:The results show that the extract of R. serpentin a leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.
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