IL-6/IL-6R as a potential key signaling pathway in prostate cancer development

作     者：Andreia Azevedo Virginia Cunha Ana Luisa Teixeira Rui Medeiros 

作者机构：Molecular Oncology and VirologyPortuguese Institute of Oncology4200-072 PortoPortugal Research Department of Portuguese League against Cancer(NRNorte)4200-072 PortoPortugal CEBIMEDFaculty of Health Sciences of Fernando Pessoa University4200-150 PortoPortugal ICBASAbel Salazar Institute for the Biomedical SciencesUniversity of Porto4200-072 PortoPortugal 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2011年第2卷第12期

页      面：384-396页

学科分类：10[医学] 

基　　金：Calouste Gulbenkian Foundation Science and Technology Foundation [FCT/PTDC/SAU-FCF/71552/2006] 

主　　题：Androgen receptor Castration-resistant prostate cancer Hormonal castration Inteuleukin-6 Inteuleukin-6 receptor Prostate cancer Tumor biomarker 

摘      要：Interleukin-6(IL-6)is a pleiotropic cytokine involved in prostate regulation and in prostate cancer(PC)development/***-6 acts as a paracrine and autocrine growth stimulator in benign and tumor prostate *** levels of IL-6 and respective receptors are increased during prostate carcinogenesis and tumor *** studies reported that increased serum and plasma IL-6 and soluble interleukin-6 receptor levels are associated with aggressiveness of the disease and are associated with a poor prognosis in PC *** PC treatment,patients diagnosed with advanced stages are frequently submitted to hormonal castration,although most patients will eventually fail this therapy and die from recurrent castration-resistant prostate cancer(CRPC).Therefore,it is important to understand the mechanisms involved in *** pathways have been proposed to be involved in CRPC development,and their understanding will improve the way to more effective *** fact,the prostate is known to be dependent,not exclusively,on androgens,but also on growth factors and *** signaling pathway mediated by IL-6 may be an alternative pathway in the CRPC phenotype acquisition and cancer progression,under androgen deprivation *** principal goal of this review is to evaluate the role of IL-6 pathway signaling in human PC development and progression and discuss the interaction of this pathway with the androgen recepto ***,we intend to evaluate the inclusion of IL-6 and its receptor levels as a putative new class of tumor *** IL-6/IL-6R signaling pathway may be included as a putative molecular marker for aggressiveness in PC and it may be able to maintain tumor growth through the AR pathway under androgen-deprivation *** importance of the IL-6/IL-6R pathway in regulation of PC cells makes it a good candidate for targeted therapy.