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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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biomarker evidence for changes in terrestrial organic matter input into the Yellow Sea mud area during the Holocene

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Science China Earth Sciences 2016年第6期59卷 1216-1224页

作者： WU Peng XIAO XiaoTong TAO ShuQin YANG ZuoSheng ZHANG HaiLong LI Li ZHAO MeiXuna Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Laboratory of Marine Hydrocarbon Resources and Environmental Geology Ministry of Land and ResourcesQingdao 266071China Third Institute of Oceanography State Oceanic Administration(SOA)Xiamen 361005China College of Marine Geoscience Ocean University of ChinaQingdao 266100China

We present lipid biomarker records of two cores （ZYI and ZY3） from the central South Yellow Sea mud area to investigate the changes in sources and transport processes of the sedimentary organic matter （OM） throughout the Holocene. Based on the analysis of marine biomarker content （EPB （Phytoplankton biomarker, total content of brassicasterol, dinosterol and C37-alkenones） and crenarchaeol）, and terrestrial biomarkers （En-alkanols and brGDGTs） as well as TMBR＇ and BIT index values, the marine organic matter （MOM） and terrestrial organic matter （TOM） deposition history was reconstructed. Changes in TOM and MOM were related to variations in land vegetation density and marine productivity, as well as transport processes dominated by the oceanic circulation system. The marine biomarker contents from the South Yellow Sea have generally in- creased throughout the Holocene, indicating that the increased MOM contents were mainly controlled by the strengthening of the circulation system. The terrestrial biomarkers, on the other hand, were more variable, indicating more complex influence of TOM burial in the Yellow Sea. During the Early Holocene （7200-6000 cal yr BP）, the moderate TOM input revealed by the terrestrial proxy records may result from abundant land source supply by strong river transport despite the lack of transport via circulation system. The Mid-Holocene （6000-3000 cal yr BP） was characterized by decreased terrestrial biomarker contents. The balance between the decrease in land source supply and increase of transportation by the current system of the TOM resulted in the lower but stable contents of TOM. During the Late Holocene （3000 cal yr BP to present）, the TOM deposition in the South Yellow Sea increased as the current system was further enhanced and thus transported more TOM to the central South Yellow Sea, although the land supply of TOM was further reduced.

关键词： South Yellow Sea Holocene biomarker Marine organic matter Terrestrial organic matter

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biomarker evidence for biotic and environmental change across the Cambrian Series 2–Series 3 boundary at the Wuliu- Zengjiayan section, Guizhou, China

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Science China Earth Sciences 2014年第11期57卷 2781-2790页

作者： WANG ChunJiang ZHAO YuanLong PENG Jin YANG XinLian BAI Jie LIU Yue CHEN Tao State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum College of Resource and Environment Engineering Guizhou University

The Wuliu-Zengjiayan section in Jianhe County, Guizhou Province, China has been suggested as a potential Global Stratotype Section and Point(GSSP) for the defined base of Cambrian Series 3. A molecular organic geochemical study on the Cambrian Series 2Series 3 boundary interval was carried out to reveal the biotic and environmental change during this transition. The hydrocarbons extracted from the Kaili Formation were proved to be indigenous. The various geochemical proxies such as biomarker parameter, δ13Corg, atomic H/C value of kerogen, and TOC content, co-vary along with the sedimentary column, and show a quick and significant change just across the Cambrian Series 2Series 3 boundary. The less abundance of isoprenoid hydrocarbons, the relative enrichment of midchain monomethyl branched alkanes(mmb-alkanes), the relatively negative value of δ13Corg, and the higher TOC contents may suggest that the upper Cambrian Series 2 was deposited in a relatively reducing environment with a higher organic input from cyanobacteria-predominated benthic microbial mats. On the other hand, the relative enrichment of isoprenoid hydrocarbons, the less abundance of mmb-alkanes, the relatively positive value of δ13Corg, the lower TOC contents, and the lower atomic H/C values of kerogen are combined to indicate an enhanced phytoplankton production and an increased oxygen content and nutrients in the ocean during the early Cambrian Series 3, which could have benefited the explosion of the Kaili Biota. The Wuliu-Zengjiayan section may provide a typical case to understand the co-variation of marine microbe, animal, and environment.

关键词： Wuliu-Zengjiayan Cambrian Series 2-Series 3 boundary biomarker organic carbon isotope biotic and environmentalchange

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biomarker Assemblages of Resin-Genetic Immature Source Rocks and Their Geological Significance

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Science China Chemistry 1993年第6期36卷 740-750页

作者：王铁冠 Jianghan Petroleum Institute Jingzhou 434102 PRC

In view of the exploration cases of immature coal-associated hydrocarbons in the world, it can be seen that resinite and exudatinite are important macerals in Huangxian and Baise brown coals on the basis of a random sampling investigation from twelve Chinese Tertiary coal-bearing basins, and resin-genetlc compounds, i.e. isopimarane, abietane, simonellite, retene, etc., account for 60% and more of total hydrocarbon fractions in the soluble parts of both the brown coals. Owing to the effect of redox environmental factors during sedimentary and diagenetic phases, the aromaticity of resin-genetic compounds is apparently different in both kinds of brown coals, it probably is one of the important reasons why naphthenic base or aromatic base oils have resulted.

关键词： Immature erude oils resinite exudatinite isopimarane simonellite biomarker assemblage.

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biomarker geochemistry of marine organic matter in the Hushan and Chaohu areas,Lower Yangtze region

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Chinese Journal Of Geochemistry 2011年第2期30卷 145-152页

作者： Chang, Chao Wang, Shaohua Zhu, Chen Ma, Weimeng Hu, Wenxuan Cao, Jian State Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China Ministry of Education Wuhan 430074 China

Marine strata are widely exposed in the Hushan and Chaohu areas, Lower Yangtze region. As biomarker geochemistry of the strata has not been well documented, this paper deals with the biomarker composition of representative samples collected from the Silurian, Carboniferous and Triassic systems and their geological implications, thus providing clues to marine organic matter. On the basis of experimental results, it is shown that abundant biomarkers (e.g. n-alkanes, isoprenoids, terpanes and steranes) were detected. As organic matter in the strata is highly to over mature in general based on petrologic microobservation, some biomarkers (mainly n-alkanes) except terpanes and steranes cannot reflect the source, depositional environment and maturity of organic matter. Thus, primarily based on analyses of the terpanes and steranes, it is suggested that organic matter in the Silurian and Carboniferous strata is derived mainly from lower organisms, while higher plants are predominant in the Triassic organic matter. This further indicates that the depositional environment may have transformed from the marine to continental facies in the Late Triassic. These results provide new evidence for the study of regional depositional evolution, and have enriched the study of biological composition of organic matter. In addition, the biomarker geochemistry of organic matter at high to over maturation stage is addressed.

关键词： Lower Yangtze region Hushan area Chaohu area organic matter biomarker depositional environment marine facies high to over maturation

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biomarker Records of Phytoplankton Productivity and Community Structure Changes During the Last 14000 Years in the Mud Area Southwest off Cheju Island, East China Sea

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Journal of Ocean University of China 2013年第4期12卷 611-618页

作者： YUAN Zineng XING Lei LI Li ZHANG Hailong XIANG Rong ZHAO Meixun Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of China) Ministry of Education/Qingdao Collaborative Innovation Center of Marine Science and Technology Institute of Marine Organic Geochemistry Ocean University of China CAS Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences

The ecological environment in the East China Sea(ECS)and the Yellow Sea(YS)has changed significantly due to sea-level rising and the Kuroshio incursion since the last *** this study,biomarker records of core F10B from the mud area southwest off Cheju Island(MSWCI)were generated to evaluate phytoplankton productivity and community structure changes in response to environmental evolution during the last 14 *** contents of diatom,dinoflagellate and haptophyte biomarkers(brassicasterol,dinosterol and C37alkenones)display similar trends,with increasing phytoplankton productivity during the last 14kyr due to the increased influences of the Kuroshio,and especially due to the eddy-induced upwelling during the late *** the other hand,the contents of terrestrial biomarkers(C28+C30+C32n-alkanols)and terrestrial organic matter(TOM)proxies(TMBR′and BIT)all reveal decreasing TOM input into the area around the sampling site for the 14 kyr,mostly due to sea-level *** biomarker ratios reveal a shift from a haptophyte-dominated community at 6.2 2.5 kyr BP to a diatom-dominated community at 2.5 1.45 kyr BP,likely caused by a stronger cold eddy circulation system at 2.5 1.45 kyr BP in the MSWCI.

关键词： biomarker East China Sea productivity community structure TMBR BIT

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biomarker evidence for paleoenvironmental changes in the southern Yellow Sea over the last 8200 years

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Chinese Journal of Oceanology and Limnology 2012年第1期30卷 1-11页

作者： XING Lei ZHAO Meixun ZHANG Hailong ZHAO Xiaochen ZHAO Xiaohui YANG Zuosheng LIU Chuanlian Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China College of Marine Geoseience Ocean University of ChinaQingdao 266100China Sate Key Laboratory Of Marine Geology School of Ocean and Earth SciencesTongji UniversityShanghai 200092China

Previous studies have indicated that the Yellow Sea underwent significant environmental changes during the Holocene, but many questions remain concerning the timing of the establishment of the modern circulation system, which would have major implications for the Yellow Sea ecosystem and carbon cycle. In this study, marine and terrestrial biomarkers were analyzed in Core YE-2 from a muddy area in the southern Yellow Sea to reconstruct Holocene environmental and phytoplankton community change. The content of three individual marine phytoplankton biomarkers (alkenones, brassicasterol and dinosterol) all display a similar trend, and their total contents during the early Holocene (362 ng/g) were lower than those during the mid-late Holocene (991 ng/g). On the other hand, the contents of terrestrial biomarkers (C27+C29+C31n-alkanes) during the early Holocene (1 661 ng/g) were about three times higher than those during the mid-late Holocene (499 ng/g). Our biomarker results suggest that the modern circulation system of the Yellow Sea was established by 5-6 ka, and resulted in higher marine productivity and lower terrestrial organic matter inputs. biomarker ratios were used to estimate shifts in phytoplankton community structure in response to mid-Holocene (5-6 ka) environmental changes in the Yellow Sea, revealing a transition from a dinoflagellate-diatom dominant community structure during the early Holocene to a coccolithophore-dominant community structure during the mid-late Holocene.

关键词： biomarker Yellow Sea muddy area paleoproductivity phytoplankton community structure

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biomarker Records of Phytoplankton Productivity and Community Structure Changes in the Central Yellow Sea Mud Area During the Mid-Late Holocene

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Journal of Ocean University of China 2013年第4期12卷 639-646页

作者： ZHAO Xiaochen TAO Shuqin ZHANG Rongping ZHANG Hailong YANG Zuosheng ZHAO Meixun Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of China) Ministry of Educa-tion/Qingdao Collaborative Innovation Center of Marine Science and Technology Institute of Marine Organic Geochemistry Ocean University of China College of Marine Geoscience Ocean University of China

The Yellow Sea （YS） environmental and ecological changes during the Holocene are driven by the interactions between the Yellow Sea Warm Current （YSWC）, the East Asian Winter Monsoon （EAWM） and the Kuroshio Current （KC）. We report marine biomarker records of brassicasterol, dinosterol and C37 alkenones in core ZY1 and core ZY2 from the South Yellow Sea （SYS） to reconstruct the spatial/temporal variations and possible mechanisms of phytoplankton primary productivity and community structure changes during the Mid-late Holocene. The contents of the corresponding biomarkers in the two cores are similar, and they also reveal broadly similar temporal trends. From 6kyr to 3kyr, the biomarker contents in the two cores were relatively low with small oscillations, followed by a distinct increase at about 3 kyr indicating productivity increases caused by a stronger EAWM. The alkenone/brassicasterol ratio （A/B） is used as a community structure proxy, which also showed higher values in both cores since 3 kyr, indicating increased haptophyte contribution to total productivity. It is proposed that the YS community structure has been mainly influenced by the YSWC, with stronger YSWC influences causing an increase in haptophyte contribution since 3 kyr. Some differences of the biomarker records between ZY2 and ZYI suggest spatial variations in response to YSWC and KC forcing. When the KC was intensified during the periods of 6-4.2kyr and 1.7-0kyr, the YSWC extended eastward, exerting more influence on core ZY1. On the other hand, when the KC weakened during 4.2-1.7 kyr, the YSWC extended westward, exerting more influence on the ZY2.

关键词： biomarker South Yellow Sea productivity community structure Yellow Sea Warm Current East Asian Winter Monsoon Kuroshio Current

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biomarker identification of thyroid associated ophthalmopathy using microarray data

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1482-1488页

作者： Hong-Bin Yang Jie Jiang Lu-Lu Li Huang-Qiang Yang Xiao-Yu Zhang Department of Ophthalmology the First Affiliated Hospital of Harbin Medical University Department of Neurosurgery the Second Affiliated Hospital of Harbin Medical University

AIM： To uncover the underlying pathogenesis of thyroid associated ophthalmopathy（TAO） and explore potential biomarkers of this ***： The expression profile GSE9340, which was downloaded from Gene Expression Omnibus database, included 18 specimens from 10 TAO patients and 8 hyperthyroidism patients without ophthalmopathy. The platform was HumanRef-8 v2 Expression BeadChip. Raw data were normalized using preprocess. Core package and the differentially expressed genes（DEGs） were identified based on t-test with limma package of R. Functional enrichment analyses were performed recruiting the DAVID tool. Based on STRING database, a protein-protein interaction（PPI） network was constructed, from which a module was extracted. The functional enrichment for genes in the module was performed by the BinGO ***： In total, 861 DEGs（433 up-regulated and 428 down-regulated） between TAO patients and hyperthyroidism patients without ophthalmopathy were identified. Crucial nodes in the PPI network included TPX2, CDCA5, PRC1, KIF23 and MKI67, which were also remarkable in the module and all enriched in cell cycle process. Additionally, MKI67 was highly correlated with TAO. Besides, the DEGs of GTF2 F1, SMC3, USF1 and ZNF263 were predicted as transcription factors（TFs）. CONCLUSION： Several crucial genes are identified such as TPX2, CDCA5, PRC1 and KIF23, which all might play significant roles in TAO via the regulation of cell cycle process. Regulatory relationships between TPX2 and CDCA5 as well as between PRC1 and KIF23 may ***, MKI67 may be a potent biomarker of TAO, and SMC3 and ZNF263 may exert their roles as TFs in TAO progression.

关键词： microarray thyroid associated ophthalmopathy cell cycle biomarker

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Multiplexed Profiling of Extracellular Vesicles for biomarker Development

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Nano-Micro Letters 2022年第1期14卷 59-94页

作者： Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason Davis George K.Tofaris Nuffield Department of Clinical Neurosciences New Biochemistry BuildingUniversity of OxfordOxford OX13QUUK Department of Chemistry University of OxfordOxford OX13QZUK School of Life and Health Sciences The Chinese University of Hong KongShenzhen 518172People’s Republic of China Dermatology Hospital Southern Medical UniversityGuangzhou 510091People’s Republic of China Kavli Institute for Nanoscience Discovery New Biochemistry BuildingUniversity of OxfordOxfordUK

Extracellular vesicles(EVs)are cell-derived membranous particles that play a crucial role in molecular trafficking,intercellular transport and the egress of unwanted *** have been implicated in many diseases including cancer and *** are detected in all bodily fluids,and their protein and nucleic acid content offers a means of assessing the status of the cells from which they *** such,they provide opportunities in biomarker discovery for diagnosis,prognosis or the stratification of diseases as well as an objective monitoring of *** simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application,and multiplexing platforms have evolved with the potential to achieve ***,we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis,with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power,throughput and consistency.

关键词： Multiplexed profiling Extracellular vesicles Exosomes Liquid biopsy Point-of-care biomarker

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