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Evaluation of Analgesic Properties of Piper Nigrum Essential Oil: a Randomized, Double-blind,Placebo-controlled Study

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World Journal of Traditional Chinese Medicine 2016年第2期2卷 60-64页

作者： R.Costa J.Machado C.Abreu Institute of Biomedical Sciences Abel Salazar University of Porto LABIOMEP-Porto Biomechanics Laboratory University of Porto FP-ENAS Research Unit UFP Energy Environment and Health Research Unit CEBIMED Biomedical Research Center Fernando Pessoa University

Objective: Essential oils are complex mixtures of chemical compounds, extracted from a wide range of plants. The volatile fraction of essential oils is responsible for their characteristic aroma and presents diverse biological properties that have been studied over the years. In Traditional Chinese Medicine, Piper nigrum is considered to be pungent and hot. Although its chemical constituents and respective pharmacological properties have been described by several authors, the volatile fraction is still underestimated as a therapeutic agent. The aim of this study was to evaluate the analgesic properties of the volatile fraction of Piper nigrum essential oil, in patients presenting different types of ***: Fifty-four patients presenting pain, were included in a randomized, double-blind, placebo-controlled study, over a 9-week *** patients were randomly divided into two groups, and asked to inhale a vial containing Piper nigrum essential oil, or a vial containing a placebo(sesame oil), for 15 minutes. A numerical pain scale was applied before and after the ***: Results showed a statistically significant decrease in pain intensity in the patients that inhaled the black pepper essential oil, while the placebo group patients showed no significant change in pain ***: Although the results are preliminary due to the limited sample size and short inhalation time, the volatile fraction of the Piper nigrum essential showed promising results in reducing pain. In the Chinese medicine perspective, these results support the use of black pepper in different types of pain, since it warms the center and disperses cold.

关键词： Piper nigrum essential oil placebo pain

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Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies

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Acta Pharmaceutica Sinica B 2021年第4期11卷 925-940页

作者： Cláudia Pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina Silva UCIBIO/REQUIMTE MedtechLaboratory of Pharmaceutical TechnologyDepartment of Drug SciencesFaculty of PharmacyUniversity of PortoPorto 4050-313Portugal CNC-Center for Neuroscience and Cell Biology Center for Innovative Biomedicine and Biotechnology(CIBB)University of CoimbraFaculty of Medicine(Pólo I)Coimbra 3004-504Portugal UC-University of Coimbra CIBBFaculty of PharmacyPólo Das Ciências da SaúdeCoimbra 3000-548Portugal FP-ENAS(UFP Energy Environment and Health Research Unit)CEBIMED(Biomedical Research Centre)Faculty of Health SciencesUniversity Fernando PessoaPorto 4249-004Portugal

The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the *** the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising *** addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc *** review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain *** on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal *** results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried *** the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the *** systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years.

关键词： Nose-to-brain delivery Intranasal administration Nanostructured lipid carriers NLC Solid lipid nanoparticles SLN Nanoemulsions In vivo studies Pharmacokinetic Pharmacodynamics

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Ovarian cancer and DNA repair: DNA ligase IV as a potential key

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World Journal of Clinical Oncology 2013年第1期4卷 14-24页

作者： Joana Assis Deolinda Pereira Rui Medeiros Molecular Oncology GRP-CI Portuguese Institute of Oncology4200-072 PortoPortugal Research Department of Portuguese League against Cancer(NRNorte) 4200-072 PortoPortugal Oncology Department Portuguese Institute of Oncology4200-072 PortoPortugal ICBAS Abel Salazar Institute for the Biomedical SciencesUniversity of Porto4200-072 PortoPortugal cebimed Faculty of Health Sciences of Fernando Pessoa University4200-150 PortoPortugal

Ovarian cancer(OC)is the sixth most common cancer and the seventh cause of death from cancer in *** etiology and the ovarian carcinogenesis still need clarification although ovulation may be determinant due to its carcinogenic role in ovarian surface *** link between ovarian carcinogenesis and DNA repair is well established and it became clear that alterations in DNA damage response may affect the risk to develop *** are variations in the DNA sequence that exist in normal individuals of a population and are capable to change,among other mechanisms,the balance between DNA damage and cellular ***,genetic variability of the host has a great role in the development,progression and consequent prognosis of the oncologic patient as well as in treatment *** treatment for OC patients is based on cytoreductive surgery,followed by chemotherapy with a platinum agent and a *** 80%of the patients respond to the first-line therapy,the development of resistance is common although the mechanisms underlying therapy failure remain mostly *** of their role in oncology,enzymes involved in the DNA repair pathways,like DNA Ligase IV(LIG4),became attractive study *** has been reported that variations in LIG4 activity can lead to a hyper-sensitivity to DNA damage,deregulation of repair and apoptosis mechanisms,affecting the susceptibility to cancer development and therapy *** overcome resistance mechanisms,several investigations have been made and the strategy to target crucial molecular pathways,such as DNA repair,became one of the important areas in clinical *** review aims to elucidate the link between DNA repair and OC,namely which concerns the role of LIG4 enzyme,and how genetic polymorphisms in LIG4 gene can modulate the activity of the enzyme and affect the ovarian carcinogenesis and treatment ***,we try to understand how LIG4 inhibition can be a potential cont

关键词： Ovarian Cancer DNA Repair DNA ligase IV Polymorphisms Susceptibility Treatment response

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循环DNA与非小细胞肺癌:过往发现与新视角

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国际病理科学与临床杂志 2013年第6期33卷 471-472页

作者： Raquel Catarino Ana Coelho Rui Medeiros 刘伟吴绮楠 Molecular Oncology Group Investigation Center Portuguese Institute of Oncology Abel Salazar Institute for the Biomedical Sciences Research Department Portuguese League Against Cancer Faculty of Health Sciences of Fernando Pessoa University CEBIMED 吉林大学第一医院呼吸内科长春130021 第三军医大学附属西南医院内分泌科重庆400030

肺癌是一个全球性问题。50％的患者被确诊时已经进展为无法治愈的晚期疾病，尽管临床医生不断努力，但各种化学治疗（化疗）方案获得的疗效均很有限。

关键词：非小细胞肺癌循环DNA 全球性问题临床医生化学治疗

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IL-6/IL-6R as a potential key signaling pathway in prostate cancer development

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World Journal of Clinical Oncology 2011年第12期2卷 384-396页

作者： Andreia Azevedo Virginia Cunha Ana Luisa Teixeira Rui Medeiros Molecular Oncology and Virology Portuguese Institute of Oncology4200-072 PortoPortugal Research Department of Portuguese League against Cancer(NRNorte) 4200-072 PortoPortugal cebimed Faculty of Health Sciences of Fernando Pessoa University4200-150 PortoPortugal ICBAS Abel Salazar Institute for the Biomedical SciencesUniversity of Porto4200-072 PortoPortugal

Interleukin-6(IL-6)is a pleiotropic cytokine involved in prostate regulation and in prostate cancer(PC)development/***-6 acts as a paracrine and autocrine growth stimulator in benign and tumor prostate *** levels of IL-6 and respective receptors are increased during prostate carcinogenesis and tumor *** studies reported that increased serum and plasma IL-6 and soluble interleukin-6 receptor levels are associated with aggressiveness of the disease and are associated with a poor prognosis in PC *** PC treatment,patients diagnosed with advanced stages are frequently submitted to hormonal castration,although most patients will eventually fail this therapy and die from recurrent castration-resistant prostate cancer(CRPC).Therefore,it is important to understand the mechanisms involved in *** pathways have been proposed to be involved in CRPC development,and their understanding will improve the way to more effective *** fact,the prostate is known to be dependent,not exclusively,on androgens,but also on growth factors and *** signaling pathway mediated by IL-6 may be an alternative pathway in the CRPC phenotype acquisition and cancer progression,under androgen deprivation *** principal goal of this review is to evaluate the role of IL-6 pathway signaling in human PC development and progression and discuss the interaction of this pathway with the androgen recepto ***,we intend to evaluate the inclusion of IL-6 and its receptor levels as a putative new class of tumor *** IL-6/IL-6R signaling pathway may be included as a putative molecular marker for aggressiveness in PC and it may be able to maintain tumor growth through the AR pathway under androgen-deprivation *** importance of the IL-6/IL-6R pathway in regulation of PC cells makes it a good candidate for targeted therapy.

关键词： Androgen receptor Castration-resistant prostate cancer Hormonal castration Inteuleukin-6 Inteuleukin-6 receptor Prostate cancer Tumor biomarker

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