Ovarian cancer and DNA repair: DNA ligase IV as a potential key
Ovarian cancer and DNA repair: DNA ligase IV as a potential key作者机构：Molecular Oncology GRP-CIPortuguese Institute of Oncology4200-072 PortoPortugal Research Department of Portuguese League against Cancer(NRNorte)4200-072 PortoPortugal Oncology DepartmentPortuguese Institute of Oncology4200-072 PortoPortugal ICBASAbel Salazar Institute for the Biomedical SciencesUniversity of Porto4200-072 PortoPortugal CEBIMEDFaculty of Health Sciences of Fernando Pessoa University4200-150 PortoPortugal
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2013年第4卷第1期
页 面：14-24页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Ovarian Cancer DNA Repair DNA ligase IV Polymorphisms Susceptibility Treatment response
摘 要：Ovarian cancer(OC)is the sixth most common cancer and the seventh cause of death from cancer in *** etiology and the ovarian carcinogenesis still need clarification although ovulation may be determinant due to its carcinogenic role in ovarian surface *** link between ovarian carcinogenesis and DNA repair is well established and it became clear that alterations in DNA damage response may affect the risk to develop *** are variations in the DNA sequence that exist in normal individuals of a population and are capable to change,among other mechanisms,the balance between DNA damage and cellular ***,genetic variability of the host has a great role in the development,progression and consequent prognosis of the oncologic patient as well as in treatment *** treatment for OC patients is based on cytoreductive surgery,followed by chemotherapy with a platinum agent and a *** 80%of the patients respond to the first-line therapy,the development of resistance is common although the mechanisms underlying therapy failure remain mostly *** of their role in oncology,enzymes involved in the DNA repair pathways,like DNA Ligase IV(LIG4),became attractive study *** has been reported that variations in LIG4 activity can lead to a hyper-sensitivity to DNA damage,deregulation of repair and apoptosis mechanisms,affecting the susceptibility to cancer development and therapy *** overcome resistance mechanisms,several investigations have been made and the strategy to target crucial molecular pathways,such as DNA repair,became one of the important areas in clinical *** review aims to elucidate the link between DNA repair and OC,namely which concerns the role of LIG4 enzyme,and how genetic polymorphisms in LIG4 gene can modulate the activity of the enzyme and affect the ovarian carcinogenesis and treatment ***,we try to understand how LIG4 inhibition can be a potential cont
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