Potential prognostic biomarkers in pancreatic juice of resectable pancreatic ductal adenocarcinoma

作     者：Shefali Agrawal 

作者机构：Hepatobiliary and Pancreatic SurgeryDepartment of Surgical OncologyIndraprastha Apollo Hospitals 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2017年第8卷第3期

页      面：255-260页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Prognostic biomarkers Pancreatic juice Bile Pancreatic adenocarcinoma Surgery 

摘      要：Despite potentially curative surgery pancreatic cancer has a dismal *** cancer antigen 19-9(CA 19-9) correlates with tumor burden,resectability and survival in patients with pancreatic ductal *** of novel biomarkers may facilitate early diagnosis of pancreatic cancer and improve *** juice is a rich source of cancer-specific proteins rendering it a promising tool for identifying *** proteomic and micro RNA expression analyses have identified several biomarkers of potential diagnostic and prognostic *** markers CA 19-9 and carcinoembryonic antigen(CEA) are widely used in the characterization of premalignant and malignant lesions of the *** level of CEA in bile is a marker for malignancy and a predictor of hepatic *** potential value of CA 19-9,CEA and lactate dehydrogenase as prognostic biomarkers in pancreatic juice and bile is *** of pancreatic juice and bile can be readily collected during surgical resection of the *** of pancreatic juice and bile to identify novel prognostic biomarkers may improve selection of patients for adjuvant therapy with a favorable impact on overall survival in patients diagnosed with pancreatic cancer.