Helicobacter pylori may be an initiating factor in newly diagnosed ulcerative colitis patients: A pilot study

作     者：Loai Mansour Ferial El-Kalla Abdelrahman Kobtan Sherief Abd-Elsalam Mohamed Yousef Samah Soliman Lobna Abo Ali Walaa Elkhalawany Ibrahim Amer Heba Harras Maha M Hagras Mohamed Elhendawy 

作者机构：Tropical Medicine and Infectious Diseases Department Faculty of Medicine Tanta University Hepatology and Gastroenterology Department Faculty of Medicine Kafr El-Sheikh University Pathology Department Faculty of Medicine Tanta University Clinical Pathology Department Faculty of Medicine Tanta University 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2018年第6卷第13期

页      面：641-649页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Ulcerative colitis Immunohistochemical staining Inflammatory bowel disease Helicobacter pylori Giemsa stain 

摘      要：AIM To directly visualize Helicobacter pylori(H. pylori) by the highly sensitive and specific technique of immunohistochemical staining in colonic tissue from patients newly diagnosed with ulcerative colitis(UC).METHODS Colonoscopic biopsies from thirty patients with newly diagnosed UC and thirty controls were stained with Giemsa stain and immunohistochemical stain for detection of H. pylori in the colonic tissue. Results were confirmed by testing H. pylori Ag in the stool then infected patients were randomized to receive either anti H. pylori treatment or *** Twelve/30(40%) of the UC patients were positive for H. pylori by Giemsa, and 17/30(56.6%) by immunohistochemistry stain. Among the control group 4/30(13.3%) and 6/30(20 %) were positive for H. pylori by Giemsa and immunohistochemistry staining respectively. H. pylori was significantly higher in UC than in controls(P = 0.04 and 0.007). All Giemsa positive patients and controls were positive by immunohistochemical stain. Four cases of the control group positive for H. pylori also showed microscopic features consistent with early *** H. pylori can be detected in colonic mucosa of patients with UC and patients with histological superficial ulcerations and mild infiltration consistent with early UC. There seems to be an association between UC and presence of H. pylori in the colonic tissue. Whether this is a causal relationship or not remains to be discovered.