Bioactive thionic compounds and aromatic glycosides from Ligusticum chuanxiong

作     者：Xu Zhang Bing Han Ziming Feng Jianshuang Jiang Yanan Yang Peicheng Zhang 

作者机构：State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2018年第8卷第5期

页      面：818-824页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by the National Natural Science Foundation of China (No.81773588) 

主　　题：Ligusticum chuanxiong Hort. Thionic compounds Aromatic glycosides Anti-inflammatory Natural products 

摘      要：Three new thionic compounds,(S)-2-(2-carboxyl-2-hydroxyethylthio)-ferulic acid(1),(E)-2-methoxy-4-(3-(methylsulfonyl)prop-1-en-1-yl)phenol(2), and thiosenkyunolide C(3), together with two new aromatic glycosides(4 and 5) were isolated from the rhizome of Ligusticum chuanxiong Hort. Two known compounds(6 and 7) were also obtained. Their structures were elucidated based on extensive spectroscopic data(UV, IR, 1D and 2D NMR, and HR-ESI-MS). Furthermore the absolute configurations were established by comparison of their calculated and experimental circular dichroism spectra and by a dimolybdenum tetraacetate [Mo_2(AcO)_4]-induced circular dichroism procedure. All compounds were evaluated against lipopolysaccharide(LPS)-induced NO production in BV2 cells, and compounds 4 and 5 showed strong inhibitory activities with IC_(50) values of 2.03 and 3.09 μmol/L, respectively(positive control curcumin, IC_(50)=6.17 μmol/L). In addition, compound 1 showed weak proteintyrosine phosphatase-1 B(PTP1B) inhibitory activity.