前列腺素而非一氧化氮是鳟主动脉内皮细胞舒血管因子(英文)
Prostaglandins but not nitric oxide are endothelium-derived relaxing factors in the trout aorta作者机构：Departments of Surgery and Physiology and Bio-physics Mayo Clinic and Foundation 200 First Street SW Rochester MN 55905 USA Institut De Recherches Internationales Servier 6 place des Pléiades 92415 Courbevoie Cedex France
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2000年第21卷第10期
页 面：10-15页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：Project supported in part by grants from the National Institutes of Health HL 31183 the Mayo Clinic and Foundation
摘 要：AIM:To identify the type of prostanoids produced by endothelial cells of trout aorta and to determine whether or not the smooth muscle responds to nitric oxide. METHODS:Ventral aortas, with and without endotheli-um from rainbow trout (S gairdneri), were incubated in a buffered salt solution. RESULTS:Addition of the calcium ionophore A23187 caused a significant increase in prostaglandin E s and a consistent increase in the stable metabolite of prostacyclin (6-keto-prostaglandin F1a) in the incubation media only when the endothelium was present. This production was inhibited by methylene blue (10umol/L). In rings of trout aorta without endothelium suspended for the measurement of isometric force in organ chambers,prostacyclin and prostaglandin E1 but not prostaglandin E2 caused concentration-dependent decreases in tension when the rings were contracted with acetyl-choline. The smooth muscle did not relax to nitric oxide but did so to sodium nitroprusside. Relaxations to the latter nitrovasodilator were no
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