Neural Activation by Milnacipran and Memory Extinction
Neural Activation by Milnacipran and Memory Extinction作者机构：Department of Anatomy I Showa University School of Medicine Tokyo Japan Department of Neuropsychiatry Faculty of Medicine Tottori University Tottori Japan Department of Psychiatry Teikyo University Chiba Medical Center Chiba Japan
出 版 物：《Journal of Behavioral and Brain Science》 (行为与脑科学期刊（英文）)
年 卷 期：2012年第2卷第2期
页 面：141-145页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Milnacipran Passive Avoidance Task Prefrontal Cortex Nucleus Accumbens Hippocampus Septum
摘 要：Background: Among neurotransmitter influencing memory formation, the noradrenergic system has been recognized as an important system. Memory formation involves various regions including the prefrontal cortex, hippocampus, amygdala and septum. Method: We investigated the effects of milnacipran on passive avoidance task and evaluated Fos counting in the prefrontal cortex, hippocampus, septum, amygdala and nucleus accumbens. Results: The milnacipran-treated rats (20 mg/kg, 4 days) showed a significant decrease in the number of Fos-immunoreactive cells in the infralimbic portion of prefrontal cortex, the shell portion of nucleus accumbens and the CA1 region of hippocampus, but a significant increase in the Fos counts in the lateral septum with no changes in the Fos counts in the striatum and amygdala. The milnacipran-treated rats showed amelioration in memory extinction (although not statistically significant), but not in memory acquisition and consolidation in the passive avoidance test. Conclusion: The differential activation of the brain regions might be possible sites for ameliorating memory extinction as well as antidepressant effects.
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