KSHV strategies for host dsDNA sensing machinery

作     者：Hang Gao Yanyan Song Chengrong Liu Qiming Liang Hang Gao Yanyan Song Chengrong Liu Qiming Liang

作者机构：Department of Nephrology The Second Hospital of Jilin University Changchun 130041 China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2016年第31卷第6期

页      面：466-471页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by a Special Fellow Award from The Leukemia & Lymphoma Society the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher learning 

主　　题：dsDNA interferon innate autophagy signaling modulate pathogen alarm initiate contributions 

摘      要：The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase(cGAS)to sense cytosolic double-stranded(ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi s Sarcoma-associated Herpesvirus(KSHV) and their contributions to KSHV life cycles.