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Lamin A/C modulate Apoptosis of Rat Vascular Smooth Muscle Cells During Cyclic Stretch Application

医用生物力学 2019年第A1期34卷 79-80页

作者： Han Bao Haipeng Li Qian Shi Kai Huang Yingxin Qi Institute of Mechanobiology&Medical Engineering School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai200240China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Beijing AdvancedInnovation Center for Biomedical Engineering Beihang UniversityBeijing100083China

Objective The apoptosis of vascular smooth muscle cells(VSMCs)influenced by abnormal cyclic stretch is crucial for vascular remodeling during hypertension.We explored that the causes of mechano-responsive lamin A/C changingin aonormai cyclic stretcn and its roles in VSMC apoptosis.Methods and results Our previous vascular proteomics study revealed that LaminA/C is mechano-sensitive molecule.When VSMCs are subjected to cyclic stretch,the expression of LaminA/C is significantly changed which participates dysfunctions of VSMCs during hypertension.However,the molecular mechanism involved in regulation of LaminA/C expression and the role of LaminA/C in the VSMC apoptosis during cyclic stretch application are still unclear.In the present study,VSMCs were subjected to different amplitudes of cyclic steetch in vitro:5%cyclic stretch(physiological strain)or 15%cyclic stretch(pathological strain).The expression of 2 different selective cleavage isomers of LaminA/C,i.e.LaminA and LaminC,and the apoptosis of VSMCs were detected.The results showed that compared with 5%group,15%cyclic stretch significantly decreased the expression of LaminA and LaminC,and promoted the apoptosis of VSMCs.Using specific small interfering RNA(siRNA)transfection which targets on LMNA the encoding gene of LaminA/C,the expression of LaminA and LaminC in VSMCs was significantly decreased,and the apoptosis was significantly increased.In order to study the molecular mechanism involved in cyclic stretch regulating the expression of LaminA/C,we focused on the microRNA(miR).Bioinformatics analysis showed that the 3’untranslated region(3’UTR)of LMNA has two potential binding sites to miR-124-3p.Double luciferase reported system revealed that both sites have binding abilities to miR-124-3p.Under static condition,miR-124-3p inhibitor significantly up-regulated the expression levels of LaminA and LaminC,while the miR-124-3p mimics significantly down-regulated them.RT-PCR results showed that 15%cyclic stretch significantly up-regulated the expression of miR-12

关键词： Lamin A/C modulate Apoptosis Rat Vascular Smooth Muscle Cells Cyclic Stretch Application

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Recent Insights into Brassinosteroid Signaling in Plants： Its Dual Control of Plant Immunity and Stomatal Development

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Molecular Plant 2012年第6期5卷 1179-1181页

作者： Xiangpei Kong Jiaowen Pan Guohua Cai Dequan Li State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop BiologyCollege of Life SciencesShandong Agricultural UniversityTai'anShandong 271018China

Brassinosteroid （BR） signaling, plant innate immunity, and stomatal developments are three pathways that are initiated by receptor-like kinases. This commentary focuses on the lat- est findings in the role of BR signaling in plant immunity and stomatal development that provide some insight into the molecular mechanism of the BR signal pathway interacting with other receptor signaling pathways.

关键词： RECEPTOR KINASE BAK1 modulate

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Nimodipine modulates Bcl-2 and Bax mRNA Expression after Cerebral Ischemia

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第2期24卷 170-172页

作者：刘昌勤周瑞祥孙圣刚 Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology

In order to explore whether the member of Bcl-2 gene family, for example, Bcl-2 and Bax, are induced after cerebral ischemia, and whether expression of genes can be modulated by calcium-antagonist, the rat cerebral ischemic models were made by occluding left middle cerebral artery. The expression of Bcl-2 and Bax mRNA was measured by RT-PCR method. After middle cerebral artery occlusion (MCAO), the expression of both Bcl-2 and Bax mRNA were induced. Level of Bcl-2 mRNA increased steadily and level of Bax mRNA increased gradually at first, reached a peak after 24 h, then decreased slowly. After administration of nimodipine, Bcl-2 mRNA was up-regulated in the hippocampus 6 and 24h after ischemia, while Bax mRNA was down-regulated 6 and 24 h after ischemia. Focal cerebral ischemia can induce proto-oncogenes to express, which was associated with apoptosis. Calcium-antagonist can up-regulate Bcl-2 mRNA and down-regulate Bax mRNA. The increased ratio of Bcl-2 and Bax mRNA may contribute to the anti-apoptic effect of nimodipine. The study indicates that pharmacological modulation of Bcl-2 family member expression could become a new strategy to manage neuronal damage.

关键词： cerebral ischemia nimodipine modulate Bcl-2 and Bax mRNA

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A Study of LD Modulation Property by Pulse Prebias Technique

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Chinese Journal of Lasers 1997年第5期6卷 429-434页

作者： JIN Enshun SHI Jiawei ZHANG Yujun(Dept. of Electronics Engineering, Jilin University, Changchun 130023, China State KeyLaboratory on Integrated Optoelectronics, Jilin University Region, Changchun 130023, China) Jilin Univ Changchun China

The pulse prebias technique is firstly applied to study on the modulation properties of the LD, high speed LED, and integrated laser transmitter. The results obtained from this technique agree well with those from DC... 详细信息

关键词： modulate modulation bandwidth

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CEMS STUDY OF modulateD AMORPHOUS Fe_(78)B_(13)Si_9/Si FILMS

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Chinese Science Bulletin 1989年第10期34卷 823-827页

作者：毕耜云李卫东梅良模 Department of Physics Shandong University Jinan

Recently there has been a great interest in the study of various compositionmodulated films because they possess noval physical properties which are different from natural materials. The modulated films formed by comb... 详细信息

关键词： modulate diffusion profile interface amorphous film.

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Angucyclines as signals modulate the behaviors of Streptomyces coelicolor

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Science Foundation in China 2015年第2期23卷 41-41页

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Yang Keqian’s laboratory at the Institute of Microbiology,Chinese Academy of Sciences,repo... 详细信息

关键词： modulate modulating antibiotic consequences microbial intriguing phenotypic producer physiological morphological

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AN AC-MODULATION EXPERIMENT IN CT-6 TOKAMAK

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Chinese Science Bulletin 1982年第5期27卷 487-490页

作者：王龙 Institute of Physics Academia Sinica

Ⅰ. INTRODUCTIONIt has been proposed and carried out to modulate plasma current in tokamak device with an AC-component. Its purpose was either to measure minor radius of plasma and conductivity distribution, or to car... 详细信息

关键词： stabilization radius modulate carry stabilizing heating minor stabilize stainless winding

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Measuring the Density of SF6 by Use of the Principle of Optical Refraction

Measuring the Density of SF6 by Use of the Principle of Opti...

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ICEMI'2005第七届国际电子测量与仪器学术会议

作者： Xu Hui Li Danmei Che Jiansheng Wu Xuefei (School of Information Science & Engineering Shenyang University of Technology Shenyang 110023 China) ( Shenyang Financial School Shenyang 110031 China)

Considering the electromagnetic situation in measuring the density of SF6, the conception of refrangibility is introduced and the relation between the matter’s density and the refractive index is set

关键词： Refractive index optic fiber gas density measurement modulate PSD.

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ON THE THEORETICAL ANALYSIS AND SPECULATION OF RF PULSE

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Chinese Journal of Biomedical Engineering(English Edition) 1993年第4期2卷 153-154页

作者： Qiang Ji Dept.of Medical Image,Tianjin Second Medical College,Tianjin 300203,China

The method of producing a complete MRI image is based on the analysis of freeinduction decay.It mainly studies when and how magnetic vector revests its initialstate after RF pulse,but neglects the effect of the RF form.In this paper we mainlystudy this.We give the mathematic expression of RF pulse which can theoreticallyimprove image （?）ality.In MRI,B1 （t） is the alternate electromagnetic excitationfield,it can be expressed as follows:

关键词： alternate producing transitional decay steep interested request modulate

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LKB1 as the keyregulator of non-small cell lung cancer plasticity and therapeutic response

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Science Foundation in China 2015年第3期23卷 15-页

Supported by the National Natural Science Foundation of China and the National Basic Research Program of China,a research team led by Prof.Ji Hongbin at Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,and Prof.Chen Haiquan from Shanghai Cancer Hospital of Fudan University,reported that LKB1inactivation elicits a redox imbalance to modulate non-small cell lung

关键词： plasticity imbalance modulate redox metabolism coo

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