Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea

作     者：Ezeja Maxwell I Ezeigbo Ihechiluru I Madubuike Kelechi G Udeh Nkiru E Ukweni Iheanacho A Akomas Stella C Ifenkwe Daniel C 

作者机构：Department of Veterinary PhysiologyPharmacology and BiochemistryCollege of Veterinary MedicineMichael Okpara University of AgricultureUmudikeAbia StateNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第2期

页      面：147-150页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Pterocarpus erinaceus Castor oil Entropooling Diarrhea Charcoal meal Diphenoxylate Atropine sulphate 

摘      要：Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in ***:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar *** activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of ***:The extract at the doses used caused a significant(P 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.