Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson＇s disease in the northern Han Chinese population
Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson＇s disease in the northern Han Chinese population作者机构：China Med Univ Sch Forens Med Shenyang 110001 Liaoning Peoples R China China Med Univ Hosp 1 Dept Neurol Shenyang 110001 Liaoning Peoples R China Baotou Med Coll Dept Forens Med Baotou 014060 Inner Mongolia Peoples R China Dalian Univ Affiliated Xinhua Hosp Dept Neurosurg Dalian 116021 Liaoning Peoples R China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2012年第125卷第4期
页 面：588-592页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 070601[理学-气象学] 071007[理学-遗传学] 0706[理学-大气科学]
主 题：Parkinson disease PARK9 PARK15 BST1 genetic association studies
摘 要：Background Parkinson＇s disease （PD） is an autosomally inherited neurodegenerative disease in elderly *** etiology of PD has long been thought to be associated with both genetic and environmental *** explore potential genetic risk factors for PD in the northern Han Chinese population,we investigated three single nucleotide polymorphisms （SNPs） （rs4538475,rs11107 and rs12564040） in the BST1,PARK15 and PARK9 *** Genomic DNA from 215 PD patients and 212 matched controls was amplified in two independent PCR systems and subsequently genotyped by digestion with the endonuclease *** parameter and association studies were carried out with SPSS 13.0 and PLINK 1.07 *** We could accurately detect all genotypes in the three loci with the PCR-RFLP or mismatched PCR-RFLP *** observed heterozygosities of the rs4538475 and rs11107 loci in PD and control groups ranged from 0.460-0.481 and 0.410-0.441,in BST1,PARK15 respectively,while we detected no heterozygosity at the rs12564040 locus in *** similar distributions of genotypic frequency between both groups suggest that the three SNPs investigated in this study are unlikely to play roles as common risk factors or pathogenic mutations for PD in northern Han *** The SNPs investigated in the BST1,PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population.
维普期刊数据库