Current knowledge on diabetic retinopathy from human donor tissues

作     者：Jessica H Eisma Jennifer E Dulle Patrice E Fort 

作者机构：Departments of Ophthalmology and Visual SciencesKellogg Eye CenterUniversity of Michigan 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2015年第6卷第2期

页      面：312-320页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学] 

基　　金：NEI NIH HHS [R01 EY020895] Funding Source: Medline NIDDK NIH HHS [P30 DK020572] Funding Source: Medline 

主　　题：Retina Diabetic retinopathy Human donor Physiopathology Vascular disease Inflammation Neurodegeneration 

摘      要：According to the American Diabetes Association,diabetes was the seventh leading cause of death,and diabetic retinopathy the leading cause of blindness in working age adults in the United States in *** is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance,and over time,this chronic metabolic condition may lead to various complications including kidney failure,heart attacks,and retinal *** order to better understand the molecular basis of this disease and its complications,animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body,including the ***,inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human *** difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications,especially diabetic retinopathy,on tissues from human *** review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to the main aspects of diabetic retinopathy:retinal vasculature dysfunction,inflammation,and *** review discusses the importance of those studies to discriminate and establish the relevance of the findings obtained from animal models but also the limitations of such approaches.