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Research 2022年第4期2022卷 283-294页

作者： Chenglin Jiang Jingsheng Miao Danwen Zhang Zhenhua Wen Chuluo Yang Kai Li Shenzhen Key Laboratory of New Information Display and Storage Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen 518055China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China

Organic push-pull systems featuring through-space charge transfer(TSCT)excited states have been disclosed to be capable of exhibiting thermally activated delayed fluorescence(TADF),but to realize high-efficiency long-wavelength emission still remains a challenge.Herein,we report a series of strongly emissive orange-red and red TSCT-TADF emitters having(quasi)planar and rigid donor and acceptor segments which are placed in close proximity and orientated in a cofacial manner.Emission maxima(λ_(em))of 594−599 nm with photoluminescence quantum yields(PLQYs)of up to 91%and delayed fluorescence lifetimes of down to 4.9μs have been achieved for new acceptor-donor-acceptor(A-D-A)molecules in doped thin films.The presence of multiple acceptors and the strong intramolecularπ-stacking interactions have been unveiled to be crucial for the efficient low-energy TSCT-TADF emissions.Organic light-emitting diodes(OLEDs)based on the new A-D-A emitters demonstrated electroluminescence with maximum external quantum efficiencies(EQEs)of up to 23.2%for the red TSCT-TADF emitters.An EQE of 18.9%at the brightness of 1000 cd m^(-2) represents one of the highest values for red TADF OLEDs.This work demonstrates a modular approach for developing high-performance red TADF emitters through engineering through-space interactions,and it may also provide implications to the design of TADF emitter with other colours.

关键词： emitter OLED donor

Early relaparotomy following pediatric living-donor liver transplantation:experience in an Indonesian national referral hospital

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World Journal of Pediatric Surgery 2023年第1期6卷 42-47页

作者： Tri Hening Rahayatri Alif Rizqy Soeratman Rusdah Binti Muhammad Amin Dalia Benchamas Margiadi Riana Pauline Tamba Mureo Kasahara Division of Pediatric Surgery Department of SurgeryRumah Sakit Umum Pusat Nasional Dr Cipto MangunkusumoCentral JakartaIndonesia Division of Pediatric Surgery Department of SurgeryUniversitas Indonesia Fakultas KedokteranCentral JakartaIndonesia Department of Surgery Rumah Sakit Umum Pusat Nasional Dr Cipto MangunkusumoCentral JakartaIndonesia Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo Central JakartaIndonesia Department of Transplantation National Center for Child Health and DevelopmentSetagaya-kuJapan

Background Living donor liver transplantation(LDLT)remains the only curative treatment for children with end-stage liver disease;however,complications of the procedure are associated with indications for early relaparotomy.Several risk factors associated with early relaparotomy after liver transplantation include pediatric end-stage liver disease(PELD)score,warm ischemia time(WIT),and cold ischemia time(CIT).Our study investigated the incidence and indications of early relaparotomy in postoperative pediatric LDLT recipients and compared the outcomes with patients who did not require relaparotomy.Methods A retrospective cohort study of pediatric LDLT recipients from Cipto Mangunkusumo Hospital,Jakarta,Indonesia,was collected from 2010 to August 2022.Indications for early relaparotomy were investigated.Factors analyzed in the early relaparotomy group compared with the nonrelaparotomy group included intraoperative blood loss,surgery duration,CIT,WIT,and PELD score.Results The highest indication for early relaparotomy was biliary leakage.Most patients who underwent early relaparotomy only had one incidence of relaparotomy(60%).The surgery duration in subjects with early relaparotomy was longer by a median of 3 hours compared with those without early relaparotomy(p=0.289).Intraoperative blood loss was greater in early relaparotomy subjects than in subjects without early relaparotomy(95 vs 77mL/kg,p=0.552).Other factors,such as PELD score,CIT,and WIT,also showed no significant difference between the two groups.Conclusion Biliary leakage was the most common indication for early relaparotomy in our center.There were no preoperative or intraoperative factors that significantly influenced the incidence of early relaparotomy due to the limited sample size and the early advancement of our liver transplant center.

关键词： laparotomy pediatric donor

Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 524-529页

作者： Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG Hongfeng HUANG Jianyong WU Jianghua CHEN Rending WANG Kidney Disease Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang ProvinceHangzhou 310003China National Key Clinical Department of Kidney Diseases Hangzhou 310003China Institute of Nephrology Zhejiang UniversityHangzhou 310003China Zhejiang Clinical Research Center of Kidney and Urinary System Disease Hangzhou 310003China

There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research.

关键词： kidney throm donor

donor ductal anomaly is not a contraindication to right liver lobe donation

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 343-347页

作者： Kenneth SH Chok James YY Fung Wing Chiu Dai Sui Ling Sin Ka Wing Ma Albert CY Chan Tan To Cheung Chung Mau Lo Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina State Key Laboratory for Liver Research The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Medicine The University of Hong Kong102 Pok Fu Lam RoadHong KongChina

Background:Data of living-donor liver transplantation(LDLT)suggested that donor ductal anomaly may contribute to postoperative biliary complications in recipients and in donors.This retrospective study aimed to determine if the occurrence of postoperative biliary stricture in donors or recipients in rightlobe LDLT(RLDLT)is related to donor biliary anatomy type.Methods:We analyzed our RLDLT recipients’clinical data and those of their graft donors.The recipients were divided into 2 groups:with and without postoperative biliary stricture.The 2 groups were compared.The primary endpoints were donor biliary anatomy type and postoperative biliary complication incidence;the secondary endpoints were 1-,3-and 5-year graft and patient survival rates.Results:Totally 127 patients were included in the study;25(19.7%)of them developed biliary anastomotic stricture.In these 25 patients,16 had type A biliary anatomy,3 had type B,2 had type C,3 had type D,and 1 had type E.In the 127 donors,96(75.6%)had type A biliary anatomy,13(10.2%)had type B,6(4.7%)had type C,10(7.9%)had type D,and 2(1.6%)had type E.Biliary stricture was seen in 2 donors,who had type A biliary anatomy.None of the recipients or donors developed bile leakage.No association between the occurrence of postoperative biliary stricture and donor biliary anatomy type was found(P=0.527).Conclusions:The incidence of biliary stricture in donors or recipients after RLDLT was not related to donor biliary anatomy type.As postoperative complications were similar in whatever type of donor bile duct anatomy,donor ductal anomaly should not be considered a contraindication to donation of right liver lobe.

关键词： Living donor liver transplantation Right liver donation Biliary complications Cholangiograms Ductal anomaly

Successful liver transplantation from a donor with immune thrombocytopenia

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 299-302页

作者： Wen-Tao Yang Jing-Sheng Ma Hong-Fei Zhu Lin Zhong Qi-Gen Li Department of Organ Transplantation The Second Affiliated Hospital of Nanchang UniversityNanchang 330000China

To the Editor:Immune thrombocytopenia(ITP)is an acquired autoimmune bleeding disease,which results from a combination of humoral and cell-mediated attacks on platelets and megakaryocytes[1-3].ITP patients are always presented as heterogeneous clinical bleeding manifestations.Fatal bleeding such as intracranial hemorrhage is the main cause of death,which turns the patients into potential organ donors.Several studies indicated that the donor lymphocytes secreting autoantibody may be transferred to recipients after transplantation[4,5].

关键词： bleeding donor patients

Terlipressin versus placebo in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 76-79页

作者： Paschalis Gavriilidis Ernest Hidalgo Robert P Sutcliffe Keith J Roberts Department of Hepato-Pancreato-Biliary and Liver Transplant surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustBirmingham B152THUK Department of Hepato-Pancreatico-Biliary Surgery and Transplantation Hospital Universitari Vall d’HebronBarcelona 08035Spain

To the Editor:Terlipressin is a long-acting synthetic analogue of vasopressin,demonstrating several potential benefits in the context of living donor liver transplantation(LDLT).During the recipient hepatec-tomy,terlipressin reduces the portal flow.Consequently,it may mitigate the extent of bowel congestion following portal vein clamping.By decreasing portal hyperperfusion and hypertension,it protects the graft from further injury and improves renal blood flow.

关键词： donor liver Terlipressin

Insights in living-donor liver transplantation associated with two-stage total hepatectomy:First case in neuroendocrine tumor metastases and functional assessment techniques

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 392-395页

作者： Laurent Coubeau Samuele Iesari Paulina Henry Philippe D’Abadie Aude Vanbuggenhout Raymond Reding aTransplantation Abdominale Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium Pole de Chirurgie Experimentale et Transplantation Institut de Recherche Experimentale et CliniqueUniversite catholique de LouvainBrusselsBelgium Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’AquilaItaly Service d’anatomo-pathologie Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium Service de medecine nucleaire Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium

To the Editor:While organ shortage commonly dooms patients on waiting list,alternative options as living-donor liver transplantation(LDLT)are assiduously sought.The principles of liver surgery rule LDLT:there must be ... 详细信息

关键词： donor liver surgery

3D printing technology in open living donor nephrectomy

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Chinese Medical Journal 2022年第17期135卷 2140-2141页

作者： Jiangwei Zhang Hang Yan Wujun Xue Jin Zheng Xiao Li Lin Hao Ting Guo Ying Wang Xiaoming Ding Department of Renal Transplantation The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China

To the Editor:Thereiscurrentlya serious shortage oforgan sources.Therefore,living donorkidney is a critical source in addition to deceased donor kidney.Open donor nephrectomy is one of the most difficult operations in the field of kidney transplantation,and the core issues are the safety of the donor and the psychological stress to the surgeon,such as trying to minimize the surgical complication to the donor,maximize the success rate,and deal with the high expectation from the recipient.

关键词： donor kidney printing

Efficient Gene Targeting in Maize Using Inducible CRISPR-Cas9 and Marker-free donor Template

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Molecular Plant 2020年第8期13卷 1219-1227页

作者： Pierluigi Barone Emily Wu Brian Lenderts Ajith Anand William Gordon-Kamm Sergei Svitashev Sandeep Kumar Corteva AgriscienceTM JohnstonIA 50131USA

CRISPR-Cas9 is a powerful tool for generating targeted mutations and genomic deletions.However,precise gene insertion or sequence replacement remains a major hurdle before application of CRISPR-Cas9 technology is fully realized in plant breeding.Here,we report high-frequency,selectable marker-free intra-genomic gene targeting(GT)in maize.Heat shock-inducible Cas9 was used for generating targeted double-strand breaks and simultaneous mobilization of the donor template from pre-integratad T-DNA.The construct was designed such that release of the donor template and subsequent DNA repair activated expression of the selectable marker gene within the donor locus.This approach generated up to 4.7%targeted insertion of the donor sequence into the target locus in TO plants,with up to 86%detected donor template release and 99%mutation rate being observed at the donor loci and the genomic target site,respectively.Unlike previous in planta or intra-genomic homologous recombination reports in which the original chimeric GT plants required extensive progeny screening in the next generation to identify non-chimeric GT individuals,our method provides non-chimeric heritable GT in one generation.

关键词： donor template insertion

Supramolecular homo-and hetero-chiral donor-acceptor copolymers with distinct nanomorphology and energy transfer efficiency

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Chinese Chemical Letters 2023年第6期34卷 1-3页

作者： Yong-Jun Lv Cheng Yang College of Chemical Engineering Sichuan University of Science and EngineeringZigong 643000China College of Chemistry Sichuan UniversityChengdu 610065China

Chirality is ubiquitous in many fields such as biology,pharmacology,chemistry,and physics.It therefore is of great significance to research on chirality generation,chirality transfer,and chirality amplification effects,especially in the living process[1].Supramolecular polymerization has become an efficient tool to organize molecular building blocks based on various chiral motifs[2].

关键词： chiral transfer donor