Theranostic applications:Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy

作     者：Sergio Casciaro 

作者机构：National Council of ResearchInstitute of Clinical PhysiologyBioengineering DivisionCampus Universitario EcotekneVia per Monteroni73100 LecceItaly 

出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)

年 卷 期：2011年第3卷第10期

页      面：249-255页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：Supported by Italian Ministry of Research Apulia Region European Commission and National Council of Research 

主　　题：Intelligent nanosystems for cellular targeting Magnetic resonance and ultrasound Molecular imaging Non-ionizing diagnostic techniques Personalized medicine in the oncological and vascular field 

摘      要：Modern medicine is expanding the possibilities of receiving personalized diagnosis and therapies,providing minimal invasiveness,technological solutions based on non-ionizing radiation,early detection of pathologies with the main objectives of being operator independent and with low cost to *** research activities aim to strongly contribute to these trends by improving the capabilities of current diagnostic imaging systems,which are of key importance in possibly providing both optimal diagnosis and therapies to *** medical diagnostics,cellular imaging aims to develop new methods and technologies for the detection of specific metabolic processes in living organisms,in order to accurately identify and discriminate normal from pathological *** fact,most diseases have a molecular basis that detected through these new diagnostic methodologies can provide enormous benefits to ***,this possibility is mainly related to the use of Positron Emission Tomography,with an exposure to ionizing radiation for patients and operators and with extremely high medical *** future possible development of non-ionizing cellular imaging based on techniques such as Nuclear Magnetic Resonance or Ultrasound,would represent an important step towards modern and personalized *** the last decade,the field of nanotechnology has made important progress and a wide range of organic and inorganic nanomaterials are now available with an incredible number of further combinations with other compounds for cellular *** availability of these new advanced nanosystems allows new scenarios in diagnostic methodologies which are potentially capable of providing morphological and functional information together with metabolic and cellular indications.