检索结果-南通市图书馆

Intranasal administration nanosystems for brain-targeted drug delivery

Nano Research 2023年第12期16卷 13077-13099页

作者： Yue Jiang Xueting Pan Tao Yu Hai Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute of Functional Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

The existence of the blood-brain barrier(BBB)restricts the entry of drugs from the circulation into the central nervous system(CNS),which severely affects the treatment of neurological diseases,including glioblastoma,Parkinson’s disease(PD),and Alzheimer’s disease(AD).With the advantage of bypassing the BBB and avoiding systemic distribution,intranasal administration has emerged as an alternative method of delivering drugs to the *** delivery directly to the brain using intranasal nanosystems represents a new paradigm for neurological disease treatment because of its advantages in improving drug solubility and stability in vivo,enabling targeted drug delivery and controlled release,and reducing non-specific *** it has shown efficacy in animal models and clinical ***,this review describes the mechanisms of intranasal delivery of brain-targeted drugs,the properties of nanosystems for intranasal administration(e.g.,liposomes,nanoemulsions,and micelles),and strategies for intranasal drug delivery to enhance brain-targeted drug *** applications of nanosystems in intranasal drug delivery and disease treatment have been comprehensively *** encouraging results have been reported,significant challenges still need to be overcome to translate these nanosystems into ***,the future prospects of intranasal drug delivery nanosystems are discussed in depth,expecting to provide useful insights and guidance for effective neurological disease treatment.

关键词： intranasal administration nanosystems brain-targeted delivery neurological diseases drug delivery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Smart Supramolecular nanosystems for Bioimaging and Drug Delivery

引用

中国化学:英文版 2015年第1期33卷 59-70页

作者： Peipei Yang Lei Wang Hao Wang CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China

The application of smart supramolecular nanosystems in biomedicine increases rapidly and offers promising prospects for disease diagnostics and *** nanosystems such as liposomes,micelles,or-ganic nanoaggregates and metallic nanostructures *** been widely explored as diagnostic/therapeutic ***,we review the recent advances in supramolecular nanosystems with different builtin reporters,e.g.,fluorescent,magnetic and photoacoustic signals for *** addition,the substantial progress of supramolecular nanosystems as drug delivery carriers for cancer therapy,including chemotherapy,photothermal and photodynamic therapies is also summarized.

关键词： supramolecular chemistry nanosystems bioimaging drug delivery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theranostic applications:Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy

引用

World Journal of Radiology 2011年第10期3卷 249-255页

作者： Sergio Casciaro National Council of Research Institute of Clinical PhysiologyBioengineering DivisionCampus Universitario EcotekneVia per Monteroni73100 LecceItaly

Modern medicine is expanding the possibilities of receiving "personalized" diagnosis and therapies,providing minimal invasiveness,technological solutions based on non-ionizing radiation,early detection of pathologies with the main objectives of being operator independent and with low cost to *** research activities aim to strongly contribute to these trends by improving the capabilities of current diagnostic imaging systems,which are of key importance in possibly providing both optimal diagnosis and therapies to *** medical diagnostics,cellular imaging aims to develop new methods and technologies for the detection of specific metabolic processes in living organisms,in order to accurately identify and discriminate normal from pathological *** fact,most diseases have a "molecular basis" that detected through these new diagnostic methodologies can provide enormous benefits to ***,this possibility is mainly related to the use of Positron Emission Tomography,with an exposure to ionizing radiation for patients and operators and with extremely high medical *** future possible development of non-ionizing cellular imaging based on techniques such as Nuclear Magnetic Resonance or Ultrasound,would represent an important step towards modern and personalized *** the last decade,the field of nanotechnology has made important progress and a wide range of organic and inorganic nanomaterials are now available with an incredible number of further combinations with other compounds for cellular *** availability of these new advanced nanosystems allows new scenarios in diagnostic methodologies which are potentially capable of providing morphological and functional information together with metabolic and cellular indications.

关键词： Intelligent nanosystems for cellular targeting Magnetic resonance and ultrasound Molecular imaging Non-ionizing diagnostic techniques Personalized medicine in the oncological and vascular field

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

引用

Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang Sik Nam Dae Hoon Park Jungho Hwang Sae Kwang Ku Chul Soon Yong Jong Oh Kim Jeong Hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanotechnology-based strategies for treatment of ocular disease

引用

Acta Pharmaceutica Sinica B 2017年第3期7卷 281-291页

作者： Yuhua Weng Juan Liu Shubin Jin Weisheng Guo Xingjie Liang Zhongbo Hu College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China University of Chinese Academy of Sciences

Ocular diseases include various anterior and posterior segment diseases. Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers and pharmacologists. Although there are conventional noninvasive and invasive treatments, such as eye drops,injections and implants, the current treatments either suffer from low bioavailability or severe adverse ocular effects. Alternatively, the emerging nanoscience and nanotechnology are playing an important role in the development of novel strategies for ocular disease therapy. Various active molecules have been designed to associate with nanocarriers to overcome ocular barriers and intimately interact with specific ocular tissues. In this review, we highlight the recent attempts of nanotechnology-based systems for imaging and treating ocular diseases, such as corneal d iseases, glaucoma, retina diseases, and choroid diseases. Although additional work remains, the progress described herein may pave the way to new,highly effective and important ocular nanomedicines.

关键词： nanosystems Nanocarrier Eye Ocular disease Ocular drug delivery Therapy Diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent Advances in Directed Assembly of Nanowires or Nanotubes

引用

Nano-Micro Letters 2012年第3期4卷 142-153页

作者： Mei Liu Zhizheng Wu Woon Ming Lau Jun Yang School of Mechatronics Engineering and Automation Shanghai University State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences Green Energy and Green Manufacturing Technology R&D Center Department of Mechanical and Materials Engineering the University of West ern Ontario

Nanowires and nanotubes of diverse material compositions,properties and/or functions have been produced or fabricated through various bottom-up or top-down *** nanowires or nanotubes have also been utilized as potential building blocks for functional *** key for the integration of those nanowire or nanotube based devices is to assemble these one dimensional nanomaterials to specific locations using techniques that are highly controllable and *** such techniques should enable assembly of highly uniform nanowire/nanotube arrays with precise control of density,location,dimension or even material types of nanowires/*** assembly techniques are being developed that can quickly align and assemble large quantities of one type or multiple types of nanowires through parallel processes,including flow-assisted alignment,Langmuir-Blodgett assembly,bubble-blown technique,electric/magnetic-field directed assembly,contact/roll printing,knocking-down,etc..With these assembling techniques,applications of nanowire/nanotube based devices such as flexible electronics and sensors have been *** paper delivers an overall review of directed nanowire/nanotube assembling approaches and analyzes advantages and limitations of each *** future research directions have also been discussed.

关键词： Nanowire Nanotube Assembly Shear force Contact printing Dielectrophoresis Microfluidics nanosystems Nanodevices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New Orbital-Free Approach for Density Functional Modeling of Large Molecules and Nanoparticles

引用

Modeling and Numerical Simulation of Material Science 2015年第2期5卷 39-47页

作者： V. Zavodinsky O. Gorkusha Institute of Materials Science Russian Academy of Sciences Khabarovsk Russia Institute of Applied Mathematics Russian Academy of Sciences Khabarovsk Russia

Development of the orbital-free (OF) approach of the density functional theory (DFT) may result in a power instrument for modeling of complicated nanosystems with a huge number of atoms. A key problem on this way is calculation of the kinetic energy. We demonstrate how it is possible to create the OF kinetic energy functionals using results of Kohn-Sham calculations for single atoms. Calculations provided with these functionals for dimers of sp-elements of the C, Si, and Ge periodic table rows show a good accordance with the Kohn-Sham DFT results.

关键词： Orbital Free Kinetic Functional Modeling nanosystems

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：