Three new lignan glucosides from the roots of Scutellaria baicalensis

作     者：Hailin Long Haijing Zhang Anjun Deng Lin Ma Lianqiu Wu Zhihong Li Zhihui Zhang Wenjie Wang Jiandong Jiang Hailin Qin 

作者机构：State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2016年第6卷第3期

页      面：229-233页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from National Natural Science Foundation of China(No.81361138020) 

主　　题：Scutellaria baicalensis Roots Labiatae Lignan glucoside Baicalensinosides A–C 3 4-Dibenzyltetrahydrofuran Osteoprotegerin-activating activity Anti-osteoporotic activity 

摘      要：Three new lignan glucosides, baicalensinosides A–C(1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofurantype lignan glycoside with a mono-hydroxyl substitution at the 70-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin(OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.