Nutritional modulators of ulcerative colitis:Clinical efficacies and mechanistic view

作     者：Mi-Kyung Sung Mi-Young Park 

作者机构：Department of Food and NutritionSookmyung Women's UniversitySeoul 140-742South Korea Department of Pharmacythe Catholic University of KoreaBucheon 420-743South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第7期

页      面：994-1004页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Mid-career Research Program through the National Research Foundation of Korea funded by the Ministry of Education Science and Technology (2012R1A2A2A01046228) 

主　　题：Ulcerative colitis Intestinal microflora Immunity Inflammation Clinical Obesity Probiotics Omega-3 fatty acids Antioxidants 

摘      要：Ulcerative colitis(UC) is an inflammation-associated disease of the colon and *** onset and progress of the disease are directly influenced by the nature of the intestinal microflora,the intestinal barrier function,and the immunological responses of the *** epithelial invasion of pathogenic bacteria due to excess contact and/or barrier dysfunction is related to inflammation mediated by intestinal immune *** the etiology of UC is not clearly understood,recent studies have shown a rising incidence of UC worldwide,and this phenomenon is more prominent in Asian countries and in Asian immigrants in Western *** increased prevalence of UC also contributes to an increased risk of developing colorectal *** factors,including changes in dietary habits,have been suggested as major risk factors of UC.A systematic review showed a negative association between UC risk and vegetable intake,whereas total fat,omega-6 fatty acids and meat intake were positively associated with an increased risk of *** dietary factors and energy balance have been suggested as having important roles in inducing changes in the microbial population and intestinal barrier integrity and in regulating inflammatory immune responses,directly or *** energy intake is now known to increase pathogenic microbial ***,the application of appropriate probiotics may reverse the pathogenic progression of the *** the meantime,dietary anti-inflammatory compounds,including omega-3 fatty acids and other phytochemicals,may directly suppress inflammatory responses in the course of UC *** this review,the increased prevalence of UC and its management are interpreted from the standpoint of nutritional modulation to regulate the intestinal microflora population,intestinal epithelium permeability,and inflammatory responses.