WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Brain mesenchymal stem cells:The other stem cells of the brain?

作     者：Florence Appaix Marie-France Nissou Boudewijn van der Sanden Matthieu Dreyfus Franois Berger Jean-Paul Issartel Didier Wion 

作者机构：INSERM U836Grenoble Institut des NeurosciencesBatiment Edmond J SafraUniversité Joseph Fourier INSERM U1167 CLINATECCentre de Recherche Edmond J SafraMINATEC Campus CEA 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2014年第6卷第2期

页      面：134-143页

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：Supported by INSERM and the Ligue contre le Cancer Isère-Rhne Alpes 

主　　题：Stem cell Mesenchymal stem cell Pericyte Brain Cell plasticity Cancer stem cell Glioma Neurodegenerative disease 

摘      要：Multipotent mesenchymal stromal cells(MSC),have the potential to differentiate into cells of the mesenchymal lineage and have non-progenitor functions including *** demonstration that MSCs are perivascular cells found in almost all adult tissues raises fascinating perspectives on their role in tissue maintenance and ***,some controversies about the physiological role of the perivascular MSCs residing outside the bone marrow and on their therapeutic potential in regenerative medicine *** brain,perivascular MSCs like pericytes and adventitial cells,could constitute another stem cell population distinct to the neural stem cell *** demonstration of the neuronal potential of MSCs requires stringent criteria including morphological changes,the demonstration of neural biomarkers expression,electrophysiological recordings,and the absence of cell *** recent finding that brain cancer stem cells can transdifferentiate into pericytes is another facet of the plasticity of these *** suggests that the perversion of the stem cell potential of pericytes might play an even unsuspected role in cancer formation and tumor progression.