Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children

作     者：Yan-Ping Xu Li Liang Chun-Lin Wang Jun-Fen Fu Pei-Ning Liu Lan-Qiu Lv Yi-Min Zhu 

作者机构：Department of EndocrinologyChildren’s Hospital of Zhejiang University School of Medicine Department of Pediatrics the First Affiliated Hospital College of Medicine Zhejiang University Department of Child Health Care the Affiliated Yuying Children’s Hospital of Wenzhou Medical University Department of Child Health Care Ningbo Women and Children’s Hospital Department of Epidemiology and Biostatistics Key Laboratory of Reproductive Genetics Ministry of Education Zhejiang University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第35期

页      面：5897-5903页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Supported by Zhejiang Provincial Natural Science Foundation of China No.Y2090137 the National Key Technology R and D Program of China No.2012BAI02B03 the Fundamental Research Funds for the Central Universities Ministry of Education China No.2011KYJD008 National Natural Science Foundation of China No.J20121252 No.81200460 

主　　题：Nonalcoholic fatty liver disease Uncoupling protein 3 Single nucleotide polymorphisms 

摘      要：AIM:To confirm the hypothesis that polymorphisms of the uncoupling protein 3(UCP3)gene are associated with the occurrence of nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 250 NAFLD patients(147 malesand 103 females)and 200 healthy individuals who served as controls(control,109 males and 91 females),aged between 6 and 16 years were enrolled in this *** four non-synonymous single nucleotide polymorphisms(SNPs)in the UCP3 gene polymorphisms of rs1726745,rs3781907,rs11235972 and rs1800849,were genotyped using *** mass index(BMI),waist and hip circumference,blood pressure(BP),fasting blood glucose(FBG),insulin and lipid profiles were measured and B-ultrasound examination was performed in all ***:NAFLD patients showed risk factors for metabolic syndrome:elevated BMI,waist-to-hip ratio,BP,FBG,homeostasis model assessment-estimated insulin resistance,total triglyceride,total cholesterol and low-density lipoprotein-cholesterol,while decreased high-density lipoprotein-cholesterol level compared with the control *** GG genotype distributions of rs11235972 in the NAFLD group differed significantly from that in the control *** found that waist circumference between CC(58.76±6.45 cm)and CT+TT(57.00±5.59 cm),and hip circumference between CC(71.28±7.84 cm)and CT+TT genotypes(69.06±7.75 cm)were significantly different with and without rs1800849 variation(P0.05).CONCLUSION:A higher prevalence of rs11235972 GG genotype was observed in the NAFLD group compared with the control *** differences were observed for the other ***,there was a significant difference in body height in addition to waist and hip circumference between the CC(mutant type group)and CT+TT group with and without rs1800849 variation.