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Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children

World Journal of Gastroenterology 2013年第35期19卷 5897-5903页

作者： Yan-Ping Xu Li Liang Chun-Lin Wang Jun-Fen Fu Pei-Ning Liu Lan-Qiu Lv Yi-Min Zhu Department of Endocrinology Children’s Hospital of Zhejiang University School of Medicine Department of Pediatrics the First Affiliated Hospital College of Medicine Zhejiang University Department of Child Health Care the Affiliated Yuying Children’s Hospital of Wenzhou Medical University Department of Child Health Care Ningbo Women and Children’s Hospital Department of Epidemiology and Biostatistics Key Laboratory of Reproductive Genetics Ministry of Education Zhejiang University

AIM:To confirm the hypothesis that polymorphisms of the uncoupling protein 3(UCP3)gene are associated with the occurrence of nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 250 NAFLD patients(147 malesand 103 females)and 200 healthy individuals who served as controls(control,109 males and 91 females),aged between 6 and 16 years were enrolled in this *** four non-synonymous single nucleotide polymorphisms(SNPs)in the UCP3 gene polymorphisms of rs1726745,rs3781907,rs11235972 and rs1800849,were genotyped using *** mass index(BMI),waist and hip circumference,blood pressure(BP),fasting blood glucose(FBG),insulin and lipid profiles were measured and B-ultrasound examination was performed in all ***:NAFLD patients showed risk factors for metabolic syndrome:elevated BMI,waist-to-hip ratio,BP,FBG,homeostasis model assessment-estimated insulin resistance,total triglyceride,total cholesterol and low-density lipoprotein-cholesterol,while decreased high-density lipoprotein-cholesterol level compared with the control *** GG genotype distributions of rs11235972 in the NAFLD group differed significantly from that in the control *** found that waist circumference between CC(58.76±6.45 cm)and CT+TT(57.00±5.59 cm),and hip circumference between CC(71.28±7.84 cm)and CT+TT genotypes(69.06±7.75 cm)were significantly different with and without rs1800849 variation(P<0.05).CONCLUSION:A higher prevalence of rs11235972 GG genotype was observed in the NAFLD group compared with the control *** differences were observed for the other ***,there was a significant difference in body height in addition to waist and hip circumference between the CC(mutant type group)and CT+TT group with and without rs1800849 variation.

关键词： Nonalcoholic fatty liver disease Uncoupling protein 3 Single nucleotide polymorphisms

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