Hydrogels for the management of second-degree burns:currently available options and future promise

作     者：Katherine A.Cook Edith Martinez-Lozano Robert Sheridan Edward K.Rodriguez Ara Nazarian Mark W.Grinstaff 

作者机构：Department of ChemistryBiomedical Engineeringand MedicineBoston UniversityBostonMA02215USA Musculoskeletal Translational Innovation InitiativeCarl J.ShapiroDepartment of Orthopaedic SurgeryBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA02215USA Shriners Hospitals for Children and Burns ServiceDepartment of SurgeryMassachusetts General HospitalBostonMA02214USA Department of Orthopaedic SurgeryYerevan State Medical UniversityYerevanArmenia 

出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)

年 卷 期：2022年第10卷第1期

页      面：71-87页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the NIH(R01EB021308) Boston University for funding and supporting this research 

主　　题：Burn Wound Hydrogel Dressing Second-degree 

摘      要：Burn wounds result from exposure to hot liquids,chemicals,fire,electric discharge or *** severity ranges from first-degree injury,which is superficial,to fourth-degree injury,which exposes bone,tendons and *** assessment of burn depth and accurate wound management in the outpatient setting is critical to prevent injury progression into deeper layers of the *** progression is of particular pertinence to second-degree burns,which are the most common form of thermal *** our understanding of wound healing advances,treatment options and technologies for second-degree burn management also *** hydrogels are a class of burn wound dressings that adhere to tissue,absorb wound exudate,protect from the environment,can be transparent facilitating serial wound evaluation and,in some cases,enable facile removal for dressing *** review briefly describes the burn level classification and common,commercially available dressings used to treat second-degree burns,and then focuses on new polymeric hydrogel burn dressings under preclinical development analyzing their design,structure and *** review presents the follow key learning points:(1)introduction to the integument system and the wound-healing process;(2)classification of burns according to severity and clinical appearance;(3)available dressings currently used for second-degree burns;(4)introduction to hydrogels and their preparation and characterization techniques;and(5)pre-clinical hydrogel burn wound dressings currently being developed.