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Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and wound Healing

Research 2021年第1期2021卷 789-800页

作者： Zhongcao Wu Hui Zhuang Bing Ma Yin Xiao Bahattin Koc Yufang Zhu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Institute of Health and Biomedical Innovation Queensland University of Technology7 Brisbane 4059Australia Integrated Manufacturing Technologies Research and Application Center Sabanci UniversityTuzla 34956 IstanbulTurkey SUNUM Nanotechnology Research Center Sabanci UniversityTuzla 34956 IstanbulTurkey Faculty of Engineering and Natural Sciences Sabanci UniversityTuzla 34956 IstanbulTurkey

Melanoma is a serious malignant skin *** eliminating melanoma and healing after-surgical wounds are always challenges in clinical *** address these problems,we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels(named MCSA hydrogels)for in situ photothermal ablation of melanoma followed by the wound healing *** proposed MCSA hydrogel had controllable gelation properties,reasonable strength,and excellent bioactivity due to the incorporated calcium silicate nanowires as the in situ cross-linking agents and bioactive *** doping of manganese into calcium silicate nanowires gave them excellent photothermal effects for eradicating melanoma effectively under near infrared(NIR)***,the synergistic effect of manganese and silicon in the MCSA hydrogel effectively promotes migration and proliferation of vascular endothelial cells and promotes ***,such bifunctional bioactive hydrogels could achieve combined functions of photothermal therapy and wound healing,showing great promise for melanoma therapy and tissue regeneration.

关键词： healing wound manganese

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Multifunctional GO Hybrid Hydrogel Scaffolds for wound Healing

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Research 2023年第2期2022卷 329-342页

作者： Xiaoya Ding Yunru Yu Chaoyu Yang Dan Wu Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Reenerative Medicine Vison and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China

Hydrogel dressings have received extensive attention for the skin wound repair,while it is still a challenge to develop a smart hydrogel for adapting the dynamic wound healing ***,we develop a novel graphene oxide(GO)hybrid hydrogel scaffold with adjustable mechanical properties,controllable drug release,and antibacterial behavior for promoting wound healing.

关键词： wound healing wound

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Accelerated Cutaneous wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing

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Chinese Journal of Polymer Science 2019年第6期37卷 548-559页

作者： Wei-Ke Xu Jing-Yu Tang Zhang Yuan Cai-Yun Cai Xiao-Bin Chen Shu-Quan Cui Peng Liu Lin Yu Kai-Yong Cai Jian-Dong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University

Bacterial infection is a very troublesome issue in wound treatment, which stimulates exudate formation and severely delays the healing process. Herein, a thermogelling dressing system composed of two triblock copolymers of poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic acid-co-glycolic acid)(PLGA-PEG-PLGA) with different block lengths was developed to deliver teicoplanin(TPN), a glycopeptide antibiotic, for cutaneous wound repair. The TPN-loaded thermogel was a free-flowing sol at room temperature and formed a semi-solid gel at physiological temperature. In vitro studies demonstrated that the TPN-loaded thermogel system exhibited desired tissue adhesiveness and realized the sustained release of TPN in a fast-followed-slow manner for over three weeks. Furthermore, a full-thickness excision wound model in Sprague-Dawley(SD) rats was constructed to assess the efficacy of TPNloaded thermogel formulation. Gross and histopathologic observations implied that treatment with the thermogel formulation reduced inflammation response, promoted disposition of collagen, enhanced angiogenesis, and accelerated wound closure and maturity of SD *** combination of the bioactivity of TPN and the acidic nature of the thermogel matrix was responsible for such an enhanced wound healing process. Consequently, the TPN-loaded PLGA-PEG-PLGA thermogel is a good candidate of wound dressing for full-thickness excision wound healing.

关键词： wound dressing PLGA-PEG-PLGA thermogel Anti-infection Teicoplanin Sustained release

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Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for wound Healing

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Research 2024年第1期2023卷 107-118页

作者： Xiaocheng Wang Jinxuan Jia Mengying Niu Wenzhao Li Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China

Biological scaffolds have been widely employed in wound healing applications,while their practical efficiency is compromised by insufficient oxygen delivery to the 3-dimensional constructs and inadequate nutrient supply for the long-term healing ***,we present an innovative living Chinese herbal scaffold to provide a sustainable oxygen and nutrient supply for promoting wound *** a facile microfluidic bioprinting strategy,a traditional Chinese herbal medicine(Panax notoginseng saponins[PNS])and a living autotrophic microorganism(microalgae Chlorella pyrenoidosa[MA])were successfully encapsulated into the *** encapsulated PNS could be gradually released from the scaffolds,which promoted cell adhesion,proliferation,migration,and tube formation in *** addition,benefiting from the photosynthetic oxygenation of the alive MA,the obtained scaffolds would produce sustainable oxygen under light illumination,exerting a protective effect against hypoxia-induced cell *** on these features,we have demonstrated through in vivo experiments that these living Chinese herbal scaffolds could efficiently alleviate local hypoxia,enhance angiogenesis,and thereby accelerate wound closure in diabetic mice,indicating their great potential in wound healing and other tissue repair applications.

关键词： healing wound protective

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Injectable melatonin-loaded carboxymethyl chitosan(CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition

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Journal of Materials Science & Technology 2021年第4期63卷 236-245页

作者： Kai Chen Changci Tong Jinge Yang Peifang Cong Ying Liu Xiuyun Shi Xu Liu Jun Zhang Rufei Zou Keshen Xiao Yuyang Ni Lei Xu Mingxiao Hou Hongxu Jin Yunen Liu Shangrao Normal University the Innovation Institute of Agricultural TechnologyCollege of Life ScienceShangrao 334001China Department of Emergency Medicine the General Hospital of Northern Theater CommandLaboratory of Rescue Center of Severe Trauma PLAShenyang l10016China Jiangxi Medical College Shangrao 334001China College of Physical Education Yanshan UniversityQinhuangdao 066004China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Carboxymethyl chitosan(CMCS)-based hydrogels have antibacterial activity,and have shown the abilities of preventing wound infection,promoting cell proliferation,accelerating collagen deposition,and stimulating hyaluronic acid formation during wound *** a hormone produced by the pineal gland in humans and animals,melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells,angiogenesis,and collagen ***,the combined effects of CMCS and melatonin on wound healing remain *** CMCS-based hydrogels containing melatonin were prepared,and their healing effects were evaluated using a full-thickness cutaneous wound model in *** with the control and the hydrogel with no melatonin groups,the melatonin-loaded hydrogel significantly increased the percentage of wound closure,promoted the proliferation of granulation tissue and re-epithelialization,and accelerated collagen ***,the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide *** melatonin-loaded hydrogel also markedly increased the expression of collagen III,α-smooth muscle actin,and transforming growth factor-β1 proteins and reduced collagen I *** results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition.

关键词： healing wound inflammation

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In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic wound Healing

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Research 2022年第3期2022卷 355-365页

作者： Xiaocheng Wang Chaoyu Yang Yunru Yu Yuanjin Zhao Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325001China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Three-dimensional(3D)bioprinting has been extensively explored for tissue repair and regeneration,while the insufficient nutrient and oxygen availability in the printed constructs,as well as the lack of adaptive dimensions and shapes,compromises the overall therapeutic efficacy and limits their further ***,inspired by the natural symbiotic relationship between salamanders and algae,we present novel living photosynthetic scaffolds by using an in situ microfluidic-assisted 3D bioprinting strategy for adapting irregular-shaped wounds and promoting their *** the oxygenic photosynthesis unicellular microalga(Chlorella pyrenoidosa)was incorporated during 3D printing,the generated scaffolds could produce sustainable oxygen under light illumination,which facilitated the cell proliferation,migration,and differentiation even in hypoxic ***,when the living microalgae-laden scaffolds were directly printed into diabetic wounds,they could significantly accelerate the chronic wound closure by alleviating local hypoxia,increasing angiogenesis,and promoting extracellular matrix(ECM)*** results indicate that the in situ bioprinting of living photosynthetic microalgae offers an effective autotrophic biosystem for promoting wound healing,suggesting a promising therapeutic strategy for diverse tissue engineering applications.

关键词： healing wound printing

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Small extracellular vesicles secreted by urine-derived stem cells enhanced wound healing in aged mice by ameliorating cellular senescence

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Journal of Materials Science & Technology 2021年第4期63卷 216-227页

作者： Yongjin Sun Juntao Zhang Bi Chen Yunlong Yang Haiyan Li Xin Niu Qing Li Weidong Wu Zongping Xie Yunfeng Chen Fuyue Wu Yang Wang Department of Orthopedic Surgery Institute of Microsurgery on ExtremitiesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Med-X Research Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Ruitai Biotechnology Co. LtdShanghai 201114China

Regeneration of chronic skin wounds in tissue is still a key challenge in regenerative medicine because of the accumulation of senescent cells and increasing secretion of s¨enescence-associated secretory phenotype(SASP)in the wound ***,some studies have reported that small extracellular vesicles(sEVs)derived from stem cells can alleviate cellular senescence with very low risk of tumorigenesis and immune *** our previous studies have shown that urine-derived stem cells(USCs)can be obtained easily and noninvasively and sEVs derived from USCs(USC-sEVs)have capabilities of regenerating tissue injuries,using USC-sEVs to enhance chronic skin wound healing in aged tissue might be a feasible and efficient ***,in this study,the USC-sEVs were collected and firstly loaded in a human acellular amniotic membrane(HAAM)for controlled releasing and locating the USC-sEVs in the wound site before they were implanted into a chronic skin wound in aged *** vivo results showed that the USC-sEVs in HAAM could effectively accelerate the wound healing by ameliorating cellular senescence and reducing the secretion of SASP in the aged skin *** elucidate the mechanism,USC-sEVs were used to in vitro culture human dermal fibroblasts(HDFs)and results showed that USC-sEVs could rejuvenate senescent fibroblasts by reversing the aging phenotypes of senescent HDFs and efficiently reducing the secretion of SASP after they activated the Sirt1 ***,USC-sEVs are efficient for enhancing wound healing in aged mice by ameliorating cellular senescence.

关键词： wound urine healing

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wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn,on streptozotocin induced diabetic rats

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Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 253-259页

作者： Santram Lodhi Abhay K Singhai Department of Pharmaceutical Sciences Dr.H.S.Gour University

Objective:To evaluate wound healing potential of flavonoid fractions of Martynia annua (***) Linn,leaves in diabetic rats on the basis of folkloric information and preliminary ***:The flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column *** two concenlrations(0.2%and 0.5%w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a *** 18th days,protein content, hydroxyproline and antioxidants(SOD,CAT and GSH) level in granuloma tissues were determined. Results:The results showed that,percent wound contraction were observed significantly(Pwound healing in diabetic condition,possibly due to Gee-radical scavenging activity of plant.

关键词： Martynia annua wound healing Flavonoids Antioxidant Povidone iodine ointment Streptozotocin

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Experimental Study on Thermal Performance of FLNG Spiral wound Heat Exchanger under Sloshing Conditions

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Journal of Thermal Science 2019年第5期28卷 1042-1053页

作者： YAN Yan SUN Chongzheng HAN Hui LI Yuxing College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil & Gas Storage and Transportation Safety/Qingdao Key Laboratory of Circle Sea Oil & Gas Storage and Transportation Technology China University of Petroleum

The FLNG spiral wound heat exchanger(SWHE) is affected by the sea conditions, which leads to more complex flow process and decrease the heat transfer performance of the heat exchanger. In order to study the thermal performance of FLNG SWHE under heaving and swaying conditions, the experimental devices of FLNG SWHE and six-DOF(degree of freedom) sloshing platform were built. The effects of heaving and swaying motions on the pressure drop and heat transfer characteristics were analyzed at different sloshing amplitudes. The results showed that the heaving and swaying motions can cause the temperature rise and pressure fluctuation of SWHE, especially for swaying. The effect of sloshing on the heat transfer performance at the top of SWHE was greater than bottom. The pressure fluctuation percentage was within 7% and the amount of temperature change was less than 2℃, under the sloshing displacement among 120–255 mm.

关键词： spiral wound heat exchanger FLNG experimental sloshing

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Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats

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Acta Pharmaceutica Sinica B 2016年第2期6卷 132-140页

作者： Yuanyuan Ji Aijun Zhang Xiaobin Chen Xiaoxia Che Kai Zhou Zhidong Wang Scientific Research Center the Second Affiliated Hospital of Xi'an Jiaotong University Department of Pharmacy the Second Affiliated Hospital of Xi'an Jiaotong University Department of VIP General Surgery the Second Affiliated Hospital of Xi'an Jiaotong University

Sodium humate(HA-Na) has been topically used as a wound healing and anti-inflammatory agent in folk medicine. In the present study, HA-Na was investigated for cutaneous wound healing in Sprague–Dawley rats. HA-Na solution(1.0%, w/v) was topically administered to rats undergoing excision wound models. Healing was assessed with a recombinant bovine basic fibroblast growth factor for external use as positive control. wound healing rates were calculated on Day 3, 6, 9, 14 and 21 after injury, and tissues were also harvested after the same intervals for histological analysis. In addition, tissue hydroxyproline levels were measured. Furthermore, m RNA levels and protein expressions of transforming growth factor-β1, 2, 3(TGF-β1, 2, 3) were determined by RT-PCR and western blot. Protein expression levels of Smad-2,-3,-4 and-7 were also detected by western blot. Our study demonstrates that HA-Na has the capacity to promote wound healing in rats via accelerated wound contraction and increased hydroxyproline content. More importantly, these wound healing effects of HA-Na might be mediated through the TGF-β/Smad signaling pathway. HA-Na may be an effective agent for enhanced wound healing.

关键词： Sodium humate wound healing Transforming growth factor-β Smad Rat

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