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Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel dressing

Chinese Journal of Polymer Science 2019年第6期37卷 548-559页

作者： Wei-Ke Xu Jing-Yu Tang Zhang Yuan Cai-Yun Cai Xiao-Bin Chen Shu-Quan Cui Peng Liu Lin Yu Kai-Yong Cai Jian-Dong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University

Bacterial infection is a very troublesome issue in wound treatment, which stimulates exudate formation and severely delays the healing process. Herein, a thermogelling dressing system composed of two triblock copolymers of poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic acid-co-glycolic acid)(PLGA-PEG-PLGA) with different block lengths was developed to deliver teicoplanin(TPN), a glycopeptide antibiotic, for cutaneous wound repair. The TPN-loaded thermogel was a free-flowing sol at room temperature and formed a semi-solid gel at physiological temperature. In vitro studies demonstrated that the TPN-loaded thermogel system exhibited desired tissue adhesiveness and realized the sustained release of TPN in a fast-followed-slow manner for over three weeks. Furthermore, a full-thickness excision wound model in Sprague-Dawley(SD) rats was constructed to assess the efficacy of TPNloaded thermogel formulation. Gross and histopathologic observations implied that treatment with the thermogel formulation reduced inflammation response, promoted disposition of collagen, enhanced angiogenesis, and accelerated wound closure and maturity of SD *** combination of the bioactivity of TPN and the acidic nature of the thermogel matrix was responsible for such an enhanced wound healing process. Consequently, the TPN-loaded PLGA-PEG-PLGA thermogel is a good candidate of wound dressing for full-thickness excision wound healing.

关键词： Wound dressing PLGA-PEG-PLGA thermogel Anti-infection Teicoplanin Sustained release

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dressing OF CORUNDUM WHEEL WITH POLY CRYSTALLINE DIAMOND

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Journal of China Textile University(English Edition) 1991年第3期9卷 35-40页

作者：徐载熊顾超 Department of Mechanical Engineering

Wheel dressing is an important part of grinding, it influences not only the grinding quality ofthe workpiece,but also the cost of *** present the single point mined diamond is widelyused as dresser in *** the mined diamond is rare in nature and dear,it has a practicalsignificance to find a substituting material for the mined *** to the isotropy of PCD(polyerystalline diamond),new sharp cutting edges will expose continuously during dressing opera-tions,maintaining high dressing *** show that dressing corundum wheel,especiallydressing those for internal grinding,PCD dresser is suitable to common hardnesses,and grains ofwheels and smaller depth of *** authors consider that PCD dressing can be used to sub-stitute completely the mined diamond dresser and the cost of dressing may be reduced.

关键词： corundum,wheel,polycrystalline diamond,wear,failure dressing

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Treating aplasia cutis congenita in a newborn with the combination of ionic silver dressing and moist exposed burn ointment: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2611-2616页

作者： Guo-Feng Lei Jun-Ping Zhang Xiao-Bing Wang Xiao-Li You Jin-Ya Gao Xiao-Mei Li Mei-Ling Chen Xiu-Qin Ning Jiang-Li Sun Department of Neonatal Intensive Care Unit Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina Department of Intensive Care Unit Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina Reproductive endocrine center Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina

BACKGROUND Aplasia cutis congenita (ACC) in newborns is a condition in which congenital defects or hypoplasia is present in part of the epidermis,dermis and even subcutaneous tissue (including muscle and bones).First reported by Cordon in 1767,ACC is a rare disease with a low incidence of 1/100000 to 3/***,there are 500 cases reported *** can be accompanied by other *** onset mechanism of the disease remains unknown but is thought to be correlated to factors such as genetics,narrow uterus,foetal skin and amniotic membrane adhesion,use of teratogenic drugs in early pregnancy and viral *** SUMMARY In August 2018,we treated a newborn with ACC on the left lower limbs using a combination of ionic silver dressing and moist exposed burn ointment (MEBO) and achieved a satisfactory treatment *** skin defects were observed on the external genitals and on areas from the left foot to 3/4 of the upper left *** tissue and blood vessels were observed in the regions with skin *** following treatments were ***,the wound was rinsed with 0.9% sodium chloride solution followed by disinfection with povidone-iodine *** then MEBO was applied to the wound at a thickness of approximately 1 *** applying ionic silver dressing,the wound was covered with sterile *** wound dressing was replaced every 2-3 *** the 4-mo follow-up,the treatment outcome was *** was minimal scar tissue formation,and limb function was not *** The combination of ionic silver dressing and MEBO to ACC is helpful.

关键词： Aplasia cutis congenita Newborns Ionic silver dressing Moist exposed burn ointment

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Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 40-51页

作者： Nantaporn Namviriyachote Vimolmas Lipipun Yada Akkhawattanangkul Phingphol Charoonrut Garnpimol C.Ritthidej Faculty of Pharmaceutical Sciences Chulalongkorn UniversityBangkok 10330Thailand Faculty of Veterinary Science Mahidol UniversityNakhon Pathom 73170Thailand

Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,*** foam was instantly formed by interaction of polyols and *** methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing *** the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active *** natural polyols formulations,foam sheets with alginate showed the highest silver and AS ***-cytotoxicity of these foam sheets to human fibroblast cells was *** testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other *** pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic *** conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment.

关键词： Polyurethane foam dressing Natural polyols Silver nanoparticles Asiaticoside Wound healing

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Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 130-143页

作者： Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai Shenyang Pharmaceutical University School of Pharmacy Shenyang Pharmaceutical University School of Medical Devices Shenyang Pharmaceutical University

Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer(DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection,change of inflammatory responses, lack of extracellular matrix(ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient(API)or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing(ND)that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU.

关键词： Nanofibers Nanofibrous dressing Diabetic foot ulcer Uniaxial electrospinning Coaxial electrospinning

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Generalized dressing method for the extended two-dimensional Toda lattice hierarchy and its reductions

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Science China Mathematics 2011年第2期54卷 365-380页

作者： LIU XiaoJun GAO Can Department of Applied Mathematics China Agricultural University Beijing 100083 China

In this paper, we solve the extended two-dimensional Toda lattice hierarchy (ex2DTLH) by the generalized dressing method developed in Liu-Lin-Jin-Zeng (2009). General Casoratian determinant solutions for this hierarchy are obtained. In particular, explicit solutions of soliton-type are formulated by using the τ-function in the form of exponential functions. The periodic reduction and one-dimensional reduction of ex2DTLH are studied by finding the constraints. Many reduced systems are shown, including the periodic ex2DTLH, sinh-Gordon equation with self-consistent sources and one-dimensional Toda lattice hierarchy with self-consistent sources. The general solutions of reduced hierarchies are found from the Casoratian solutions of ex2DTLH, by considering additional constraints during the dressing procedure.

关键词： extended Toda lattice hierarchy dressing reduction sinh-Gordon self-consistent sources soliton

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Efficacy of combination of localized closure,ethacridine lactate dressing,and phototherapy in treatment of severe extravasation injuries:A case series

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World Journal of Clinical Cases 2021年第18期9卷 4599-4606页

作者： Yan-Xu Lu Ying Wu Peng-Fei Liang Rong-Chan Wu Ling-Yun Tian Hui-Ying Mo Xiangya Stomatological Hospital&School of Stomatology Central South UniversityChangsha 410000Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Department of Burn and Reconstructive SurgeryXiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Burn and Reconstructive Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Phase 1 Clinical Trial Center Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina School of Nursing Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND The management of severe extravasation injuries is still *** injuries can be treated in many *** To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and *** In this study,we evaluated the data of eight patients,including six from the Department of Burn,one(with colorectal carcinoma)from the Veteran Cadre Department,and one(with leukemia)from the Hematology *** these,three patients were male and five were *** of the patients ranged from 10 mo to 72 years,including two children(10 and 19 mo of age).In this study,the infusion was stopped immediately when the extravasation was *** extravasation event was managed routinely using a blocking solution.A ring-shaped localized closure was performed using the blocking ***,ethacridine lactate dressing and phototherapy were applied for 3-5 *** In this study,the drugs contained in the infusates were iodixanol,norepinephrine,alprostadil,amino acids,fat emulsion,cefoselis,cefoxitin,and potassium chloride+concentrated sodium *** of the patients achieved complete healing after treatment and no obvious adverse reactions were *** The treatment of severe extravasation injuries using a combination of localized closure,ethacridine lactate dressing,and phototherapy resulted in satisfactory outcomes in patients.

关键词： Extravasation Closure Ethacridine lactate dressing Phototherapy Treatment

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β-Chitin/Chitosan Obtained from Loligo and Humboldt Squids Effectiveness as Wound dressing Material

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Journal of Donghua University(English Edition) 2013年第5期30卷 406-409页

作者： JINDAN Rahim ZALAL Rahim HUDSON Samuel KING W Martin College of Textiles North Carolina State University College of Textiles Donghua University

A number of materials are utilized to develop wound care dressing materials with metallic treatments such as ionic silver and zinc. Metallic ions if used for a prolonged time may lead to toxicity. Alternatively chitin,a natural polysaccharide found in nature, is utilized. It is found in fungi, crabs, mushrooms,squids, octopus, and many other living organisms. Chitin has similar structure to cellulose but its deacetylated derivate chitosan has amine groups that provide potential antibacterial properties along with a number of other advantages. Chitin in its natural form is found in three different structural forms,namely α,β,and γ.The β-chitin and chitosan are mostly found in the exoskeleton of squids. Loligo and Humboldt squids were studied. It is anticipated that Humboldt chitin is more effective in serving as antibacterial material and can be utilized for wound care. Differences in steriochemical structure were observed among β-chitin structures obtained and amine group's presences were found along with ability of materials to swell.

关键词： β-chitin chitosan wound dressing material

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Beneficial effects of a novel shark-skin collagen dressing for the promotion of seawater immersion wound healing

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Military Medical Research 2018年第2期5卷 117-128页

作者： Xian-Rong Shen Xiu-Li Chen Hai-Xia Xie Ying He Wei Chen Qun Luo Wei-Hong Yuan Xue Tang Deng-Yong Hou Ding-Wen Jiang Qing-Rong Wang The PLA Key Laboratory of Biological Effect and Medical Protection on Naval Vessel Special Environment Naval Medical Research InstituteShanghai 200433China College of Food Science and Technology Shanghai Ocean UniversityShanghai 201306China Research Center of TCM Processing Technology Zhejiang Chinese Medical UniversityHang Zhou 311401China

Background: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing which should be suitable to prevent the wound from seawater immersion and to promote the wound ***: Shark skin collagen(SSC) was purified via ethanol de-sugaring and de-pigmentation and adjusted for p H. A shark skin collagen sponge(SSCS) was prepared by freeze-drying. SSCS was attached to an anti-seawater immersion polyurethane(PU) film(SSCS+PU) to compose a new dressing. The biochemical properties of SSC and physicochemical properties of SSCS were assessed by standard methods. The effects of SSCS and SSCS+PU on the healing of seawaterimmersed wounds were studied using a seawater immersion rat model. For the detection of SSCS effects on seawaterimmersed wounds, 12 SD rats, with four wounds created in each rat, were divided into four groups: the 3 rd day group, 5 th day group, 7 th day group and 12 th day group. In each group, six wounds were treated with SSCS, three wounds treated with chitosan served as the positive control, and three wounds treated with gauze served as the negative control. For the detection of the SSCS+PU effects on seawater-immersed wounds, 36 SD rats were divided into three groups: the gauze(GZ)+PU group, chitosan(CS)+PU group and SSCS+PU group, with 12 rats in each group, and two wounds in each rat. The wound sizes were measured to calculate the healing rate, and histomorphology and the immunohistochemistry of the CD31 and TGF-β expression levels in the wounded tissues were measured by standard ***: The results of Ultraviolet-visible(UV-vis) spectrum, Fourier-transform infrared(FTIR) spectrum, circular dichroism(CD) spectra, sodium

关键词： Anti-seawater immersion dressing Shark skin collagen Seawater immersion wound Wound healing

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Anode Simulation and Cathode Design for Electrolytic dressing of Diamond Profile Wheel

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Transactions of Tianjin University 2005年第3期11卷 172-175页

作者：邹峰于爱兵谭业发 Key Laboratory for Advanced Ceramics and Machining Technology of Education Ministry School of Mechanical Engineering Tianjin University Tianjin 300072 China Nanjing Engineering Institute Nanjing 210007 China

The design methods of anode and cathode are proposed for precision profile grinding. Based on the electrolytic machining theory, electrolytic equilibrium condition and Faraday′s law of electrolysis are applied to establishing the mathematical model of profile diamond dressing process- es. A finite element method (FEM) program is developed to solve the inverse boundary problem of Laplace′s equation. Desired anode contour or cathode shape is determined by computing the distribution of electric potential layer by layer. Electrolytic machining experiment is carried out to verify the simulated anode shape. The research result shows that shape deviation between designed cathode and profile wheel increases with the value of angle between feed rate and the normal to anode surface. The shape of simulated anode is consistent with the contour of metal-bonded diamond profile wheel for a given cathode. Based on the anode contour, cathode shape can also be designed accurately.

关键词： profile wheel dressing electrolysis FEM diamond

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