In vitro antioxidant and anti-inflammatory activities of Korean blueberry(Vaccinium corymbosum L.) extracts
In vitro antioxidant and anti-inflammatory activities of Korean blueberry(Vaccinium corymbosum L.) extracts作者机构：Department of Applied BiochemistryKonkuk UniversityChungju 380-701Korea
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2014年第4卷第10期
页 面：807-815页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by Basic Science Program through the National Research Foundation of Korea funded by the Ministry of Education Science and Technology(Grant No.2012-A419-0147)
主 题：Phenolics Flavonoids DPPH radical scavenging Nitrite scavenging DNA damage Antiinflammatory activity
摘 要：Objective:To investigate in vitro antioxidant and anti-inflammatory activities of Korean blueberry(Vaccinium corymbosum L.).Methods:Total phenolic and flavonoid contents of the Korean blueberry water and ethanol extracts were determined before determining the potential of the extracts as *** activity of the extracts was determined by following some well established methods for free radical scavenging such as 2,2-diphenyl-picrylhydrazyl hydrate,1,2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonicacid),free radical induced DNA damage,superoxide dismutaselike and catalase assay ***,1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan and nitric oxide assay were performed to determine the anti-inflammatory activity of the ***:Total phenolic contents were found(115.0±3.0) and(4.2±3.0) mg GAE/100 g fresh mass for both extracts,respectively and flavonoid contents were(1 942.8±7.0) and(1 292.1±6.0) mg CE/100 g fresh mass for water and ethonal extracts,*** the extracts displayed significant scavenging activity of some radicals such as 2,2-diphenyl-picrylhydrazyl hydrate(IC_(50) at 1.8 mg/mL and 2.05 mg/mL,respectively),l,2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonicacid)(IC_(50) at1.5 mg/mL and 1.6 mg/mL,respectively) and nitrite(IC_(50) at 1.7 mg/mL and 1.5 mg/mL,respectively)*** extracts were found to prevent inflammation as well by reducing nitric oxide production and cytotoxicity in ***:The findings suggest that the fresh Korean blueberry could be used as a source of natural antioxidants and anti-inflammatory agents.
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