Perspectives of pluripotent stem cells in livestock

作     者：Dharmendra Kumar Thirumala R Talluri Naresh L Selokar Iqbal Hyder Wilfried A Ku 

作者机构：Animal Physiology and Reproduction DivisionICARCentral Institute for Research on BuffaloesHisar 125001India Equine Production CampusICAR-National Research Centre on EquinesBikaner 334001India Department of PhysiologyNTR College of Veterinary ScienceGannavaram 521102India Department of BiotechnologyFriedrich-Loeffler-InstituteFederal Institute of Animal HealthNeustadt 31535Germany 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第1期

页      面：1-29页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学] 

主　　题：Livestock Cellular reprogramming Chimera Cell-therapy Ontogenesis Pluripotency 

摘      要：The recent progress in derivation of pluripotent stem cells(PSCs)from farm animals opens new approaches not only for reproduction,genetic engineering,treatment and conservation of these species,but also for screening novel drugs for their efficacy and toxicity,and modelling of human *** attempts to derive PSCs from the inner cell mass of blastocyst stages in farm animals were largely unsuccessful as either the cells survived for only a few passages,or lost their cellular potency;indicating that the protocols which allowed the derivation of murine or human embryonic stem(ES)cells were not sufficient to support the maintenance of ES cells from farm *** scenario changed by the innovation of induced pluripotency and by the development of the 3 inhibitor culture conditions to support naïve pluripotency in ES cells from livestock ***,the long-term culture of livestock PSCs while maintaining the full pluripotency is still challenging,and requires further ***,we review the current achievements in the derivation of PSCs from farm animals,and discuss the potential application areas.